Kaliszan R
J Pharm Sci. 1986 Feb;75(2):187-9. doi: 10.1002/jps.2600750218.
Higher zeta-potential values were found for the crystalline particles of polymorph A when compared with polymorph B of chloramphenicol palmitate when measured at identical conditions. In the case of the thermomicroscopically prepared crystal sample being a mixture of the polymorphs, the resulting zeta potential was higher than that measured for pure form B and lower than that found for form A. It has been assumed that the zeta potential reflects differences in the surface properties of the polymorphs. These differences are briefly discussed from the point of view of the adsorption of the charge-generating ions as well as of the marked differences in bioactivity reported for the polymorphs.
在相同条件下测量时，发现棕榈氯霉素多晶型物A的结晶颗粒比多晶型物B具有更高的ζ-电位值。对于热显微镜制备的晶体样品，若其为多晶型物的混合物，则所得ζ-电位高于纯B型所测值，低于A型所测值。据推测，ζ-电位反映了多晶型物表面性质的差异。从产生电荷离子的吸附以及多晶型物报道的显著生物活性差异的角度简要讨论了这些差异。
