Tokatly Latzer Itay, Pearl Phillip L
Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel.
Epilepsia Open. 2024 Nov 26. doi: 10.1002/epi4.13108.
Creative thinking represents one of our highest-order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our adaptation and survival. Elucidating the neurobiology and neuroanatomy of creative cognition is challenging because the construct of creativity is not clearly defined, and the many neuropsychological measures attempting to assess it are often biased, leading to imprecise findings. Using examples from the medical and music fields, creativity is demonstrably linked to the default mode network (DMN), which has the unique property of becoming activated at times of "quiet wakefulness," facilitating "defaulted" internally focused cognitive operations. Creative thoughts result from a process involving the activation and deactivation of the DMN as part of a dynamic interplay shared with the central executive network and affective salience network. The question is posed whether seizures originating from DMN-related cortical areas should be considered as having overlap with eloquent cortex, potentially exempting them from removal in epilepsy surgery. PLAIN LANGUAGE SUMMARY: Creative thinking is a higher-order cognitive process involving multiple brain structures and networks. It results in insightful and original thoughts that translate to useful products or concepts, which allow us to adapt to our surroundings. This Narrative Review presents conceptual, investigational, and neurobiological aspects of creativity, including information about a unique brain network termed "default mode network (DMN)," which activates at times of "quiet wakefulness," facilitating internally focused cognitive operations. The review ends with a discussion on whether regions of the DMN from which seizures originate should be regarded as "eloquent" and their removal should be deferred by epilepsy surgery.
创造性思维是我们最高层次的认知过程之一，涉及多个皮质结构以及几个皮质和皮质下网络之间复杂的相互作用。它产生新颖的想法，这些想法可转化为有用的产品或概念。因此，创造力的进化目的显而易见，因为它促进了我们的适应和生存。阐明创造性认知的神经生物学和神经解剖学具有挑战性，因为创造力的概念没有明确定义，而且许多试图评估它的神经心理学测量方法往往存在偏差，导致研究结果不准确。以医学和音乐领域的例子来说，创造力明显与默认模式网络（DMN）相关联，该网络具有在“安静清醒”时被激活的独特特性，有助于进行“默认的”内部聚焦认知操作。创造性思维源于一个过程，该过程涉及DMN的激活和去激活，这是与中央执行网络和情感显著性网络共享的动态相互作用的一部分。问题是，源自与DMN相关的皮质区域的癫痫发作是否应被视为与明确的皮质有重叠，从而在癫痫手术中可能免于切除。
创造性思维是一种涉及多个脑结构和网络的高级认知过程。它产生有洞察力和原创性的想法，这些想法可转化为有用的产品或概念，使我们能够适应周围环境。这篇叙述性综述介绍了创造力的概念、研究和神经生物学方面，包括有关一个独特的脑网络“默认模式网络（DMN）”的信息，该网络在“安静清醒”时激活，有助于进行内部聚焦认知操作。综述最后讨论了源自DMN的癫痫发作区域是否应被视为“明确的”，以及在癫痫手术中是否应推迟切除这些区域。
