眼内乙酰胆碱与卡巴胆碱的比较。

Comparison of intraocular acetylcholine and carbachol.

作者信息

Yee R W, Edelhauser H F

出版信息

J Cataract Refract Surg. 1986 Jan;12(1):18-22. doi: 10.1016/s0886-3350(86)80049-9.

Abstract

Commercially available 1% acetylcholine chloride and 0.01% carbachol chloride, which are commonly used as miotics in intraocular surgery, have recently been reformulated. Comparative studies of these agents show similar miotic activity. However, in vitro perfusion of human corneas demonstrated that 1% acetylcholine chloride causes marked changes in endothelial function and ultrastructure as compared to carbachol or BSS Plus. This study showed that 0.01% carbachol chloride was less toxic to the corneal endothelium than 1% acetylcholine chloride and suggests that 1% acetylcholine should not be used in corneas with compromised endothelium as in primary corneal endotheliopathies.

摘要

市售的1%氯化乙酰胆碱和0.01%氯化卡巴胆碱常用于眼科手术中的缩瞳剂，最近已重新配方。对这些药物的比较研究显示出相似的缩瞳活性。然而，人角膜的体外灌注实验表明，与卡巴胆碱或平衡盐溶液（BSS Plus）相比，1%氯化乙酰胆碱会导致内皮功能和超微结构发生显著变化。这项研究表明，0.01%氯化卡巴胆碱对角膜内皮的毒性低于1%氯化乙酰胆碱，并提示在原发性角膜内皮病变等内皮功能受损的角膜中不应使用1%氯化乙酰胆碱。