Shi LuYao, Wang Jian, Wei Tao, Liang Zhang, Zhang Le, Li ChangYan, Liu Tao, Fan WenXing
Department of Nephrology, First Affiliated Hospital, Kunming Medical University, No.295, Xichang Road, Kunming, 650032, Yunnan Province, China.
Department of Nephrology, The Second People's Hospital of Baoshan City, Baoshan, Yunnan Province, China.
Int Urol Nephrol. 2025 May;57(5):1513-1531. doi: 10.1007/s11255-024-04290-4. Epub 2024 Nov 26.
There is a lack of bibliometric analysis in research regarding primary therapy for end-stage renal disease (ESRD). This study aims to analyze the literature on ESRD therapy published over the past decade to understand current conditions and study trends for future research.
Data were collected from the Web of Science Core Collection (WOSCC) database. Tools like CiteSpace 6.2.R4, 6.1.R6, VOSviewer 1.6.18, and Bibliometrix R4.1.1 were used to reveal research trends and hotspots. In addition, KEGG/GO analysis examined the probable functionalities of genes implicated in ESRD therapy to guide future research.
The bibliometric analysis presented in this paper indicates that the number of publications has remained relatively stable since 2013. The level of international collaboration is notably high, with the United States serving as the dominant research hub in this field. The University of California system is the most prolific institution, and Transplantation Proceedings is the most frequently published journal in this area. Kalantar-Zadeh, Kamyar is recognized as the most published and cited author. Keywords such as "secondary hyperparathyroidism," "uremic toxins," "cyclosporine," "mycophenolate mofetil," and "biomarkers" have seen a surge in interest recently, reflecting emerging research trends. Furthermore, inflammation and stem cell research have been identified as promising new therapeutic avenues for ESRD.
This study identifies major areas, frontiers, and trends in research on primary treatments for ESRD, providing significant implications for future research.
关于终末期肾病（ESRD）初级治疗的研究缺乏文献计量分析。本研究旨在分析过去十年发表的关于ESRD治疗的文献，以了解当前状况并研究未来研究趋势。
数据从科学网核心合集（WOSCC）数据库收集。使用CiteSpace 6.2.R4、6.1.R6、VOSviewer 1.6.18和Bibliometrix R4.1.1等工具来揭示研究趋势和热点。此外，KEGG/GO分析检查了与ESRD治疗相关基因的可能功能，以指导未来研究。
本文呈现的文献计量分析表明，自2013年以来出版物数量一直相对稳定。国际合作水平显著较高，美国是该领域的主要研究中心。加利福尼亚大学系统是最多产的机构，《移植会议录》是该领域发表最频繁的期刊。卡兰塔尔 - 扎德赫（Kamyar Kalantar-Zadeh）被认为是发表和被引用最多作品的作者。诸如“继发性甲状旁腺功能亢进”、“尿毒症毒素”、“环孢素”、“霉酚酸酯”和“生物标志物”等关键词最近受到了极大关注,反映出新兴的研究趋势。此外，炎症和干细胞研究已被确定为ESRD有前景的新治疗途径。
本研究确定了ESRD初级治疗研究的主要领域、前沿和趋势，为未来研究提供了重要启示。
