Mohite Popat, Puri Abhijeet, Munde Shubham, Ade Nitin, Kumar Ashwini, Jantrawut Pensak, Singh Sudarshan, Chittasupho Chuda
AETs St. John Institute of Pharmacy and Research, Palghar 401404, Maharashtra, India.
Research and Development Cell, School of Engineering and Technology, Manav Rachna International Institute of Research and Studies, Faridabad 121003, Haryana, India.
Gels. 2024 Nov 7;10(11):719. doi: 10.3390/gels10110719.
Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (HFMNs) represent a transformative advancement in the management of dermal diseases through non-invasive drug delivery. These innovative devices consist of micrometer-sized needles made of native or crosslinked hydrophilic polymers, capable of penetrating the stratum corneum without damaging underlying tissues. Upon insertion, HFMNs rapidly absorb interstitial fluid, swelling to form a hydrogel conduit that enables the efficient transport of therapeutic agents directly into the dermal microcirculation. The non-invasive nature of HFMNs enhances patient compliance by eliminating the pain and discomfort associated with traditional hypodermic needles. This technology allows for the delivery of a wide range of drugs, including macromolecules and biomacromolecules, which are often difficult to administer dermally due to their size and polarity. Moreover, HFMNs provide controlled and regulated release profiles, enabling sustained therapeutic effects while minimizing systemic side effects. Additionally, HFMNs can be used for both drug delivery and real-time interstitial fluid monitoring, offering valuable insights into disease states and treatment responses. This dual functionality positions HFMNs as a versatile dermatology tool capable of effectively addressing various dermal complications. This review explores the potential use of polymeric biomaterials in HFMN fabrication and their application in treating major dermal disorders, such as acne, psoriasis, and other skin conditions. Furthermore, the review highlights the non-invasive nature of MN-based treatments, underscoring their potential to reduce patient discomfort and improve treatment adherence, as supported by the recent literature.
微针（MN）技术已成为一种将治疗剂输送到皮肤的有前景的方法，在治疗各种皮肤疾病方面具有巨大潜力。在这些技术中，水凝胶形成微针（HFMN）通过非侵入性药物递送在皮肤病管理方面代表了一项变革性进展。这些创新装置由天然或交联的亲水性聚合物制成的微米级针头组成，能够穿透角质层而不损伤下层组织。插入后，HFMN迅速吸收组织间液，肿胀形成水凝胶管道，使治疗剂能够有效地直接输送到真皮微循环中。HFMN的非侵入性通过消除与传统皮下注射针头相关的疼痛和不适提高了患者的依从性。这项技术允许递送多种药物，包括大分子和生物大分子，由于其大小和极性，这些药物通常难以通过皮肤给药。此外，HFMN提供可控和调节的释放曲线，在使全身副作用最小化的同时实现持续的治疗效果。此外，HFMN可用于药物递送和实时组织间液监测，为疾病状态和治疗反应提供有价值的见解。这种双重功能使HFMN成为一种多功能的皮肤病学工具，能够有效解决各种皮肤并发症。本综述探讨了聚合物生物材料在HFMN制造中的潜在用途及其在治疗主要皮肤疾病（如痤疮、银屑病和其他皮肤状况）中的应用。此外，该综述强调了基于微针治疗的非侵入性，正如最近的文献所支持的那样，强调了它们在减轻患者不适和提高治疗依从性方面的潜力。
