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基底外侧杏仁核的振荡使生物物理模型能够进行恐惧学习。

Basolateral amygdala oscillations enable fear learning in a biophysical model.

机构信息

Department of Mathematics and Statistics, Boston University, Boston, United States.

Department of Biology, University of Southern California, Los Angeles, United States.

出版信息

Elife. 2024 Nov 26;12:RP89519. doi: 10.7554/eLife.89519.

DOI:10.7554/eLife.89519
PMID:39590510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11594530/
Abstract

The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (3-6 Hz), high theta (6-12 Hz), and gamma (>30 Hz) rhythms in the BLA local field potential recordings. However, it is not understood what role these rhythms play in supporting the plasticity. Here, we create a biophysically detailed model of the BLA circuit to show that several classes of interneurons (PV, SOM, and VIP) in the BLA can be critically involved in producing the rhythms; these rhythms promote the formation of a dedicated fear circuit shaped through spike-timing-dependent plasticity. Each class of interneurons is necessary for the plasticity. We find that the low theta rhythm is a biomarker of successful fear conditioning. The model makes use of interneurons commonly found in the cortex and, hence, may apply to a wide variety of associative learning situations.

摘要

外侧杏仁核（BLA）是发生恐惧学习的关键部位，通过突触可塑性实现。啮齿动物研究表明，BLA 局部场电位记录中存在明显的低 theta（3-6 Hz）、高 theta（6-12 Hz）和伽马（>30 Hz）节律。然而，目前尚不清楚这些节律在支持可塑性方面发挥了什么作用。在这里，我们创建了一个详细的 BLA 电路生物物理模型，以表明 BLA 中的几类中间神经元（PV、SOM 和 VIP）可能在产生节律方面起着关键作用；这些节律促进了通过尖峰时间依赖性可塑性形成的专门恐惧回路。每类中间神经元对于可塑性都是必需的。我们发现低 theta 节律是成功恐惧条件反射的生物标志物。该模型利用了通常在皮层中发现的中间神经元，因此可能适用于各种联想学习情况。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a5/11594530/303e9bc9faf3/elife-89519-app1-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a5/11594530/fde69fe7de51/elife-89519-app1-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86a5/11594530/5eeaccb418b9/elife-89519-app1-fig3.jpg
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