Kiełbowski Kajetan, Król Małgorzata, Bakinowska Estera, Pawlik Andrzej
Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Membranes (Basel). 2024 Oct 24;14(11):223. doi: 10.3390/membranes14110223.
Membrane transporters are expressed in a wide range of tissues in the human organism. These proteins regulate the penetration of various substances such as simple ions, xenobiotics, and an extensive number of therapeutics. ABC and SLC drug transporters play a crucial role in drug absorption, distribution, and elimination. Recent decades have shown their contribution to the systemic exposure and tissue penetration of numerous drugs, thereby having an impact on pharmacokinetic and pharmacodynamic parameters. Importantly, the activity and expression of these transporters depend on numerous conditions, including intestinal microbiome profiles or health conditions. Moreover, the combined intake of other drugs or natural agents further affects the functionality of these proteins. In this review, we will discuss the involvement of ABC and SLC transporters in drug disposition. Moreover, we will present current evidence of the potential role of drug transporters as therapeutic targets.
膜转运蛋白在人体多种组织中均有表达。这些蛋白质可调节各种物质的通透，如简单离子、外源性物质以及大量治疗药物。ABC和SLC药物转运蛋白在药物吸收、分布和消除过程中发挥着关键作用。近几十年来，已证实它们对众多药物的全身暴露和组织渗透有影响，进而影响药代动力学和药效学参数。重要的是，这些转运蛋白的活性和表达取决于多种条件，包括肠道微生物群谱或健康状况。此外，同时摄入其他药物或天然物质会进一步影响这些蛋白质的功能。在本综述中，我们将讨论ABC和SLC转运蛋白在药物处置中的作用。此外，我们还将介绍药物转运蛋白作为治疗靶点潜在作用的现有证据。
