Glavaš Tahtler Josipa, Cicvarić Ana, Koulenti Despoina, Karvouniaris Marios, Bogdan Maja, Kralik Kristina, Krajina Kmoniček Irena, Grbić Mlinarević Marina, Kvolik Slavica
Department of Anesthesiology, Resuscitation and Intensive Care, Osijek University Hospital, 31000 Osijek, Croatia.
Medical Faculty, University of Osijek, 31000 Osijek, Croatia.
J Fungi (Basel). 2024 Oct 28;10(11):743. doi: 10.3390/jof10110743.
The isolation of may be related to comorbidity, prolonged mechanical ventilation, and survival during intensive care unit (ICU) stay, especially with non-albicans (NAC). To examine the frequency of isolation, associated comorbidities and outcomes in the surgical ICU in Osijek University Hospital, Croatia, the data from the electronic database from May 2016 to 30 June 2023 were analyzed. In a cross-sectional study examining 15,790 microbiological samples, different strains of were observed in 581 samples from 236 patients. The control group (N = 261) was 130 consecutive patients from March to May 2019 and 131 in the same months in 2020 (pre- and post-COVID-19). Comorbidities, duration of mechanical ventilation, and survival were compared. Patients with isolated were more often non-elective and had significantly more heart, kidney, and liver diseases and sepsis than the control group ( < 0.001). The duration of mechanical ventilation was 9.2 [2.2-9.24], 96 [24-146], 160 [19.5-343], and 224 [73.5-510] hours in the controls, in patients with , in patients with NAC, and in patients with ≥2 species isolated, respectively. The mortality was significantly higher (42%) in patients with isolated than in the control group (19%, < 0.001). In a multivariate analysis adjusted for patients' age, the Simplified Acute Physiology Score II, days of ICU, and type of admission, only sepsis on admission was an independent predictor of mortality (odds ratio = 2.27).
[具体菌种名称]的分离可能与合并症、机械通气时间延长以及重症监护病房（ICU）住院期间的生存情况有关，尤其是非白色念珠菌（NAC）。为了研究克罗地亚奥西耶克大学医院外科ICU中[具体菌种名称]分离的频率、相关合并症及结局，分析了2016年5月至2023年6月30日电子数据库中的数据。在一项横断面研究中，对15790份微生物样本进行检测，在来自236例患者的581份样本中观察到不同菌株的[具体菌种名称]。对照组（N = 261）为2019年3月至5月的130例连续患者以及2020年相同月份的131例患者（COVID - 19之前和之后）。比较了合并症、机械通气时间和生存率。分离出[具体菌种名称]的患者更常为非择期手术，且与对照组相比，患有心脏、肾脏和肝脏疾病以及脓毒症的比例显著更高（P < 0.001）。对照组、分离出[具体菌种名称]的患者、分离出NAC的患者以及分离出≥2种[具体菌种名称]的患者的机械通气时间分别为9.2[2.2 - 9.24]小时、96[24 - 146]小时、160[19.5 - 343]小时和224[73.5 - 510]小时。分离出[具体菌种名称]的患者死亡率显著高于对照组（42%对19%，P < 0.001）。在对患者年龄、简化急性生理学评分II、ICU住院天数和入院类型进行校正的多变量分析中，仅入院时的脓毒症是死亡率的独立预测因素（比值比 = 2.27）。
