Turner B B, Moses L F
J Mol Cell Cardiol. 1986 Mar;18(3):331-3. doi: 10.1016/s0022-2828(86)80415-1.
We compared the binding of [3H]-dexamethasone in cytosols prepared from atria and ventricles. The effects of steroid treatment and adrenalectomy on receptor concentration were measured in both male and female rats. In male rats the distribution of receptors was similar in atria and ventricles. In contrast, the atria of female rats in all treatment groups had twice the number of receptors as did the ventricles. Adrenalectomy in females resulted in receptor up-regulation, but dexamethasone treatment, which was effective in reducing binding in males and in the ventricles of females, failed to alter atrial binding in females. These results suggest that the atria of female rats may be more responsive than ventricles to the effects of circulating glucocorticoids.
我们比较了[3H]-地塞米松在心房和心室制备的胞质溶胶中的结合情况。在雄性和雌性大鼠中均测量了类固醇处理和肾上腺切除对受体浓度的影响。雄性大鼠中，心房和心室的受体分布相似。相比之下，所有处理组的雌性大鼠心房中的受体数量是心室的两倍。雌性大鼠肾上腺切除导致受体上调，但地塞米松处理虽能有效降低雄性大鼠和雌性大鼠心室中的结合，却未能改变雌性大鼠心房中的结合。这些结果表明，雌性大鼠的心房可能比心室对循环糖皮质激素的作用更敏感。
