Department of Otorhinolaryngology, Silopi State Hospital, Sirnak.
Department of Otorhinolaryngology, Memorial Diyarbakır Hospital, Diyarbakır. Turkey.
Cir Cir. 2024;92(6):795-803. doi: 10.24875/CIRU.24000204.
The objective of the study is to evaluate combined hyperbaric oxygen therapy (HBOT) and steroids on hearing in sudden sensorineural hearing loss (SSNHL) patients.
A total of 50 patients with sudden hearing loss that started within 1 week and who received a combination of intravenous steroid therapy and HBOT in their medical treatment were assigned to the otolaryngology department for 1 week, followed by intravenous steroid therapy at 1 mg/kg/day and then reduced doses for 1 week. They were treated once in a hyperbaric chamber where they breathed 100% oxygen at 2.5 atm pressure for 60 min, for a total of 20 sessions.
Hearing loss was observed in 54% of participants in the right ear. Significant improvements were observed in hearing thresholds across all tested frequencies after treatment with a specific intervention (p < 0.001 for each comparison). Combined steroid and HBOT significantly improved hearing across low and high frequencies (p < 0.001). Improvement in hearing at low frequencies was significantly greater than at high frequencies (p < 0.01). Post hoc analysis showed greater hearing improvement at lower frequencies compared to higher ones.
This study demonstrated that combined steroid and HBOT significantly improves hearing thresholds in patients with idiopathic SSNHL, especially at lower frequencies.
本研究旨在评估联合高压氧治疗(HBOT)和类固醇对突发性聋(SSNHL)患者听力的影响。
共纳入 50 例发病 1 周内、接受静脉类固醇联合 HBOT 治疗的突发性聋患者,在耳鼻喉科接受 1 周治疗,随后给予 1mg/kg/天的静脉类固醇治疗,持续 1 周。他们在高压氧舱中接受治疗,每次呼吸 2.5 个大气压的 100%氧气 60 分钟,共 20 次。
右耳听力损失的患者占 54%。特定干预后,所有测试频率的听力阈值均有显著改善(每次比较均 p<0.001)。联合类固醇和 HBOT 可显著改善低频和高频听力(p<0.001)。低频听力改善显著大于高频听力(p<0.01)。事后分析显示,低频听力的改善显著大于高频听力。
本研究表明,联合类固醇和 HBOT 可显著改善特发性 SSNHL 患者的听力阈值,尤其是低频听力。