Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Department of Otorhinolaryngology, College of Medicine, Pusan National University, Busan, Republic of Korea.
Ann Otol Rhinol Laryngol. 2024 Apr;133(4):400-405. doi: 10.1177/00034894231222692. Epub 2024 Jan 10.
Hyperbaric oxygen therapy (HBOT) is an accepted treatment option for sudden sensorineural hearing loss (SSNHL), but it is still recommended in combination with corticosteroids. We investigated the efficacy of salvage HBOT in refractory SSNHL that does not respond to corticosteroid combination therapy.
Eighty-four patients were included, who had unilateral SSNHL with an improvement of pure-tone average (PTA) less than 10 dB after using intratympanic plus systemic corticosteroids (combined therapy) as the initial therapy. The control group (n = 66) received no further treatment, and the HBOT group (n = 18) received additional treatment with HBOT (10 sessions in total with 2.5 atmospheres absolute for 1 hour).
No differences in PTA or WDS were found between the 2 groups. However, the mean hearing gain in the HBOT group (16.8 ± 4.49 dB) was significantly higher than that in the control group (4.45 ± 1.03 dB) ( = .015). The proportion of patients with hearing recovery (hearing gain of 10 dB or more) after treatment was significantly higher in HBOT group (38.9%) than in the control group (10.6%).
In patients with refractory SSNHL after steroid combined therapy, salvage HBOT showed a significant effect on hearing gain and recovery rate.
高压氧疗法（HBOT）是治疗突发性聋（SSNHL）的一种公认的治疗方法，但仍建议与皮质类固醇联合使用。我们研究了对皮质类固醇联合治疗无效的难治性 SSNHL 进行挽救性 HBOT 的疗效。
共纳入 84 例单侧 SSNHL 患者，这些患者在接受鼓室内加全身皮质类固醇（联合治疗）作为初始治疗后，纯音平均听阈（PTA）改善小于 10dB。对照组（n=66）未接受进一步治疗，HBOT 组（n=18）接受 HBOT 治疗（共 10 次，每次 2.5 个大气压，1 小时）。
两组 PTA 或 WDS 无差异。然而，HBOT 组的平均听力增益（16.8±4.49dB）明显高于对照组（4.45±1.03dB）（ = .015）。治疗后听力恢复（听力增益 10dB 或以上）的患者比例在 HBOT 组（38.9%）明显高于对照组（10.6%）。
在皮质类固醇联合治疗后出现难治性 SSNHL 的患者中，挽救性 HBOT 对听力增益和恢复率有显著效果。
