Parkins Samuel, Song Yidong, Jaoui Yanis, Gala Aryan, Konda Kaven T, Richardson Crispo, Lee Hey-Kyoung
Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218.
Cell Molecular Developmental Biology and Biophysics Graduate Program, Johns Hopkins University, Baltimore, Maryland 21218.
J Neurosci. 2025 Jan 22;45(4):e0969242024. doi: 10.1523/JNEUROSCI.0969-24.2024.
Loss of a sensory modality triggers global adaptation across brain areas, allowing the remaining senses to guide behavior more effectively. There are specific synaptic and circuit plasticity observed across many sensory areas, which suggests potential widespread changes in activity. Here we used a cFosTRAP2 mouse line to drive tdTomato (tdT) expression in active cells to spatially map the extent of activity changes in various sensory areas in adult mice of both sexes following two modes of visual deprivation. We found that in the primary visual cortex (V1), both dark exposure (DE) and enucleation (EN) caused an initial loss of active cells followed by a partial rebound, which occurred relatively more in the superficial layers. A similar pattern was observed in the secondary visual cortex, especially in the lateral areas (V2L). The spared primary sensory cortices adapted distinctly. In the primary somatosensory barrel cortex (S1BF), there was a change in the density of active cells dependent on the duration and the mode of visual deprivation. In the primary auditory cortex (A1), there was a relative reduction in the density of active cells in the superficial layers without a significant change in the overall density. There were minimal changes in the active cell density in the secondary cortices of the spared senses and the multisensory retrosplenial cortex (RSP). Our results are consistent with cross-modal recruitment of the deprived visual cortex and compensatory plasticity in the spared primary sensory cortices that can support enhanced processing and refinement of the spared senses.
一种感觉模态的丧失会引发大脑各区域的全局适应性变化，使其余感觉能够更有效地指导行为。在许多感觉区域都观察到了特定的突触和回路可塑性，这表明活动可能发生广泛变化。在这里，我们使用cFosTRAP2小鼠品系来驱动活性细胞中tdTomato（tdT）的表达，以在空间上绘制成年雌雄小鼠在两种视觉剥夺模式后不同感觉区域活动变化的程度。我们发现，在初级视觉皮层（V1）中，黑暗暴露（DE）和眼球摘除（EN）都会导致活性细胞最初减少，随后部分反弹，这种情况在浅层相对更明显。在次级视觉皮层，尤其是外侧区域（V2L）也观察到了类似模式。未受影响的初级感觉皮层有明显的适应性变化。在初级躯体感觉桶状皮层（S1BF）中，活性细胞密度的变化取决于视觉剥夺的持续时间和模式。在初级听觉皮层（A1）中，浅层活性细胞密度相对降低，总体密度无显著变化。未受影响感觉的次级皮层和多感觉后扣带回皮层（RSP）中的活性细胞密度变化极小。我们的结果与被剥夺视觉皮层的跨模态募集以及未受影响的初级感觉皮层中的代偿性可塑性一致，这些可塑性能够支持对未受影响感觉的增强处理和优化。
