Emerg Infect Dis. 2024 Dec;30(12):2583-2592. doi: 10.3201/eid3012.240467.
We analyzed clinical manifestations, antifungal susceptibility, and treatment outcomes of cutaneous sporotrichosis in Thailand during 2018-2022. The study included 49 patients whose mean age was 58.7 (SD 16.9) years; 65.3% were female and 34.7% male. A history of cat exposure was reported in 32 (65.3%) patients who had a significantly higher prevalence of upper extremity lesions than did those without cat contact (90.6% vs. 41.7%; adjusted odds ratio 18.9 [95% CI 3.2-92.9]). Among patients >60 years of age, lesions were more likely to be nonpustular than for patients <60 years of age (82.1% vs. 52.4%; p = 0.033). All 9 isolates tested for antifungal drug susceptibility exhibited an itraconazole MIC of <1 μg/mL. Oral itraconazole monotherapy was effective; the median time-to-cure was 180 days (interquartile range 141-240 days). Physicians should heighten their awareness of potential sporotrichosis causes, particularly when a history of animal contact exists.
我们分析了 2018-2022 年期间泰国皮肤孢子丝菌病的临床表现、抗真菌药敏性和治疗结果。研究包括 49 名患者，平均年龄为 58.7（SD 16.9）岁；65.3%为女性，34.7%为男性。32 名（65.3%）患者有接触猫的病史，他们上肢病变的患病率明显高于无猫接触的患者（90.6%比 41.7%；调整后的优势比 18.9 [95%可信区间 3.2-92.9]）。60 岁以上的患者中，非脓疱性病变比 60 岁以下的患者更常见（82.1%比 52.4%；p = 0.033）。所有 9 株分离物的抗真菌药敏试验均显示伊曲康唑 MIC 值<1μg/mL。口服伊曲康唑单药治疗有效；中位治愈时间为 180 天（四分位间距 141-240 天）。医生应提高对潜在孢子丝菌病病因的认识，特别是存在动物接触史时。
