Department of Radiology, Weill Cornell Medicine, 425 East 61st Street, New York, NY, 10065, USA.
Curr Med Imaging. 2024;20:e15734056294366. doi: 10.2174/0115734056294366240826070620.
Kikuchi-Fujimoto Disease (KFD) is a rare condition, distinguished by its hallmark presentation of regional lymphadenopathy in young adult females. While initially observed to exclusively affect cervical lymph nodes in females under 40 years old, KFD is now known to impact individuals of any age or gender and manifest with adenopathy in various anatomical sites. Nonspecific imaging findings for KFD include enlarged lymph nodes, often exhibiting abnormal morphology.
In this study, we present the case of a 49 year old asymptomatic woman, in whom several enlarged left axillary lymph nodes were incidentally noted during routine mammography. The diagnosis of KFD was determined via ultrasound-guided core needle biopsy. Histological examination of the biopsied lymph node revealed necrotizing lymphadenitis, consistent with KFD.
The uncommon and broad presentation of KFD highlights the significance of acquiring tissue samples to distinguish this condition from resembling malignancies or autoimmune disorders.
Kikuchi-Fujimoto 病(KFD)是一种罕见的疾病,其特征是年轻成年女性出现区域性淋巴结病。虽然最初观察到仅影响 40 岁以下女性的颈淋巴结,但现在已知 KFD 可影响任何年龄和性别的个体,并表现为各种解剖部位的淋巴结病。KFD 的非特异性影像学表现包括淋巴结肿大,常表现为异常形态。
在本研究中,我们介绍了一例 49 岁无症状女性的病例,在常规乳腺 X 线摄影中偶然发现多个左侧腋窝淋巴结肿大。通过超声引导下的核心针活检确定了 KFD 的诊断。活检淋巴结的组织学检查显示坏死性淋巴结炎,符合 KFD。
KFD 罕见且广泛的表现强调了获取组织样本以将其与类似恶性肿瘤或自身免疫性疾病区分开来的重要性。