New Horizons in Cancer Progression and Metastasis: Signaling Pathway.

The pathway is highly evolved to maintain tissue homeostasis in diverse species by regulating cell proliferation, differentiation, and apoptosis. In tumor biology, the pathway is a prime example of signaling molecules involved in cancer progression and metastasis. core elements , and have critical roles in the maintenance of traditional tissue architecture and cell homeostasis. However, in cancer development, dysregulation of signaling results in tumor progression and the formation secondary cancers. components not only transmit biochemical signals but also act as mediators of mechanotransduction pathways during malignant neoplasm development and metastatic disease. This review confers knowledge of pathway core components and their role in cancer progression and metastasis and highlights the clinical role of pathway in cancer treatment. The signaling pathway and its unresolved mechanisms hold great promise as potential therapeutic targets in the emerging field of metastatic cancer research.