Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Department of Experimental Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Biomolecules. 2024 Oct 31;14(11):1393. doi: 10.3390/biom14111393.
Chronic kidney disease (CKD) represents a significant global health challenge, affecting millions of individuals and leading to substantial morbidity and mortality. This review aims to explore the epidemiology, cardiovascular complications, and management strategies associated with CKD, emphasizing the importance of preventing cardiovascular disease and early intervention. CKD is primarily driven by conditions such as diabetes mellitus, hypertension, and cardiovascular diseases, which often coexist and exacerbate renal impairment. Effective management requires a multifaceted approach, including lifestyle modifications, pharmacological interventions, and regular monitoring. Dietary changes, such as sodium restriction and a controlled intake of phosphorus and potassium, play a vital role in preserving renal function. Pharmacological therapies, particularly angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and emerging agents like SGLT2 inhibitors, have shown efficacy in slowing disease progression and improving patient outcomes. Furthermore, patients undergoing dialysis face increased cardiovascular risk, necessitating comprehensive management strategies to address both renal and cardiac health. As the landscape of CKD treatment evolves, ongoing research into novel therapeutic options and personalized medical approaches are essential. This review underscores the urgent need for awareness, education, and effective preventive measures to mitigate the burden of CKD and enhance the quality of life for affected individuals.
慢性肾脏病(CKD)是一个全球性的健康挑战,影响着数百万人,导致了大量的发病率和死亡率。本综述旨在探讨与 CKD 相关的流行病学、心血管并发症和管理策略,强调预防心血管疾病和早期干预的重要性。CKD 主要由糖尿病、高血压和心血管疾病等疾病引起,这些疾病通常同时存在并加重肾脏损害。有效的管理需要采取多方面的方法,包括生活方式的改变、药物干预和定期监测。饮食改变,如限制钠的摄入和控制磷和钾的摄入,对保护肾功能起着至关重要的作用。药物治疗,特别是血管紧张素转换酶(ACE)抑制剂、血管紧张素受体阻滞剂(ARBs)和新兴的 SGLT2 抑制剂,已被证明在减缓疾病进展和改善患者预后方面具有疗效。此外,接受透析的患者面临更高的心血管风险,需要综合管理策略来解决肾脏和心脏健康问题。随着 CKD 治疗领域的不断发展,对新的治疗选择和个性化医疗方法的持续研究至关重要。本综述强调了提高认识、教育和采取有效的预防措施的迫切需要,以减轻 CKD 的负担,提高受影响个体的生活质量。