Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstraße 20, 04103 Leipzig, Germany.
Biomolecules. 2024 Nov 19;14(11):1474. doi: 10.3390/biom14111474.
Serum concentrations of leucine-rich alpha-2 glycoprotein 1 (LRG1) are elevated in several cardio-metabolic and inflammatory diseases. LRG1 also plays an important role in the development of hepatic steatosis and insulin resistance. In lipodystrophies (LDs), severe cardio-metabolic complications can be observed. The dysregulation of several adipokines plays a significant role in the clinical manifestation of this syndrome. To date, there have been no studies of LRG1 levels in non-HIV-LD patients. We performed a cross-sectional analysis of LRG1 serum levels in 60 patients with non-HIV-associated LD and in 60 age-, sex-, and BMI-matched healthy controls. Furthermore, we investigated the gene expression of in a model of generalised LD. No significant difference was found in the median concentration of LRG1 serum levels between LD patients (18.2 ng/L; interquartile range 8.3 ng/L) and healthy controls (17.8 ng/L; interquartile range 11.0 ng/L). LRG1 serum concentrations correlated positively with CRP serum levels ( < 0.001). mRNA expression was downregulated in the adipose tissue, whereas in the liver, no difference in expression between LD and wild-type was detected. In summary, circulating levels of LRG1 are associated with low-grade inflammation but cannot distinguish between patients with LD and controls.
血清中富含亮氨酸的α-2 糖蛋白 1（LRG1）的浓度在几种心脏代谢和炎症性疾病中升高。LRG1 也在肝脂肪变性和胰岛素抵抗的发展中发挥重要作用。在脂肪营养不良（LDs）中，会观察到严重的心脏代谢并发症。几种脂肪因子的失调在该综合征的临床表现中起着重要作用。迄今为止，尚未有关于非 HIV-LD 患者 LRG1 水平的研究。我们对 60 名非 HIV 相关 LD 患者和 60 名年龄、性别和 BMI 匹配的健康对照者的 LRG1 血清水平进行了横断面分析。此外，我们还在全身性 LD 模型中研究了 的基因表达。LD 患者（18.2ng/L；四分位距 8.3ng/L）和健康对照组（17.8ng/L；四分位距 11.0ng/L）的 LRG1 血清水平中位数无显著差异。LRG1 血清浓度与 CRP 血清水平呈正相关（ < 0.001）。脂肪组织中 的 mRNA 表达下调，而在肝脏中，LD 和野生型 之间的 表达无差异。总之，循环 LRG1 水平与低度炎症相关，但不能区分 LD 患者和对照组。
