Martínez-Fernández Diana Emilia, Fernández-Quezada David, Garzón-Partida Andrea P, Aguilar-García Irene G, García-Estrada Joaquín, Luquin Sonia
Instituto Transdisciplinar de Investigación y Servicios (ITRANS), Universidad de Guadalajara (UdeG), Zapopan 45150, Mexico.
Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara (UdeG), Blvd. Marcelino García Barragán, Guadalajara 1421, Mexico.
Brain Sci. 2024 Oct 31;14(11):1110. doi: 10.3390/brainsci14111110.
Substance use disorder (SUD) significantly impacts public health, economics, and legal systems worldwide. Eye Movement Desensitization and Reprocessing (EMDR) was initially developed in the late 1980s as a therapeutic approach for post-traumatic stress disorder (PTSD), using bilateral stimulation to integrate traumatic memories with calming physiological responses. However, the effectiveness of EMDR in treating SUD remains unclear. This study aims to conduct a systematic review and meta-analysis of the impact of EMDR therapy on craving reduction in individuals with SUD. The search was conducted using databases such as PubMed and Web of Science, focusing on studies that measured craving and employed EMDR interventions. Both random and fixed effects models were used to pool effect sizes, utilizing an R software meta-package (R-4.4.1). The study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The results indicated a significant reduction in cravings among patients undergoing EMDR therapy. Specifically, under the fixed effect model, the standardized mean difference (SMD) was -0.866 with a 95% confidence interval ranging from -1.121 to -0.611 (z = -6.66, < 0.0001). These findings may demonstrate the significant efficacy of EMDR therapy in decreasing cravings in people with SUD.
物质使用障碍（SUD）对全球公共卫生、经济和法律体系都有重大影响。眼动脱敏再处理疗法（EMDR）最初于20世纪80年代末被开发出来，作为一种治疗创伤后应激障碍（PTSD）的方法，通过双侧刺激将创伤性记忆与平静的生理反应相结合。然而，EMDR治疗SUD的有效性仍不明确。本研究旨在对EMDR疗法对SUD患者减少渴望的影响进行系统评价和荟萃分析。使用PubMed和Web of Science等数据库进行检索，重点关注测量渴望并采用EMDR干预的研究。使用随机效应模型和固定效应模型合并效应量，利用R软件的meta包（R-4.4.1）。该研究遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南。结果表明，接受EMDR治疗的患者的渴望显著降低。具体而言，在固定效应模型下，标准化平均差（SMD）为-0.866，95%置信区间为-1.121至-0.611（z = -6.66，< 0.0001）。这些发现可能表明EMDR疗法在降低SUD患者渴望方面具有显著疗效。
