Vega-Rosas Andrés, Flores-Ramos Mónica, Ramírez-Rodríguez Gerardo Bernabé
Laboratorio de Epidemiología Clínica, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City C.P. 14370, Mexico.
Laboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco #101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City C.P. 14370, Mexico.
Brain Sci. 2024 Nov 13;14(11):1137. doi: 10.3390/brainsci14111137.
Major Depressive Disorder (MDD) is a neuropsychiatric condition whose neurobiological characteristics include alterations in brain plasticity, modulated by Brain-Derived Neurotrophic Factor (BDNF). In animal models, environmental enrichment promotes neuroplasticity and reduces depressive-like behaviors. In humans, we proposed to assess the level of Enriched Environment (EE) using a questionnaire that includes different domains of the EE (cognitive, social, and physical), which we named the EE Indicator (EEI).
To determine the relationship between the level of EE and serum BDNF in participants with MDD and healthy controls.
Participants with MDD without antidepressant treatment and healthy controls were recruited, and their EE level and serum BDNF concentration were determined looking for correlations between their clinical characteristics and the cognitive, social, and physical activities according to the EEI.
A total of 25 participants were recruited, of which 6 participants with MDD and the same number of controls were selected in a paired manner. Although no differences were found in the concentration of BDNF between the groups, positive correlations were observed between cognitive EE and BDNF (r = 0.62, = 0.035), as well as negative social EE and the Hamilton Depression Rating Scale (HDRS) (r = -0.86, = 0.001). The sum between cognitive and social EE showed a positive correlation with the serum concentration of BDNF (r = 0.34, = 0.0451).
The level of EE is potentially modulating the presence and severity of MDD at a clinical level, but it can also influence at a neuroplastic level through promoting or limiting the concentration of BDNF.
重度抑郁症（MDD）是一种神经精神疾病，其神经生物学特征包括大脑可塑性的改变，这受脑源性神经营养因子（BDNF）调节。在动物模型中，环境富集可促进神经可塑性并减少类似抑郁的行为。在人类中，我们提议使用一份问卷来评估富集环境（EE）的水平，该问卷涵盖EE的不同领域（认知、社交和身体），我们将其命名为EE指标（EEI）。
确定MDD患者和健康对照者中EE水平与血清BDNF之间的关系。
招募未接受抗抑郁治疗的MDD患者和健康对照者，根据EEI确定他们的EE水平和血清BDNF浓度，以寻找其临床特征与认知、社交和身体活动之间的相关性。
共招募了25名参与者，其中以配对方式选择了6名MDD患者和相同数量的对照者。尽管两组之间BDNF浓度没有差异，但观察到认知EE与BDNF之间呈正相关（r = 0.62，P = 0.035），以及社交EE与汉密尔顿抑郁量表（HDRS）呈负相关（r = -0.86，P = 0.001）。认知和社交EE的总和与血清BDNF浓度呈正相关（r = 0.34，P = 0.0451）。
EE水平可能在临床层面调节MDD的存在和严重程度，但它也可能通过促进或限制BDNF的浓度在神经可塑性层面产生影响。
