Obstetrics and Gynaecology Department, Centre Hospitalier Universitaire Clermont-Ferrand, 63000 Clermont-Ferrand, France.
"Translational Approach to Epithelial Injury and Repair" Team, Auvergne University, CNRS 6293, Inserm 1103, iGReD, 63000 Clermont-Ferrand, France.
Int J Mol Sci. 2024 Nov 5;25(22):11893. doi: 10.3390/ijms252211893.
The human fetal membrane is a globally accepted biological biomaterial for wound and tissue repair and regeneration in numerous fields, including dermatology, ophthalmology, and more recently orthopedics, maxillofacial and oral surgery, and nerve regeneration. Both cells and matrix components of amnion and chorion are beneficial, releasing a diverse range of growth factors, cytokines, peptides, and soluble extracellular matrix components. Beside fetal membranes, numerous natural materials have also been reported to promote wound healing. The biological properties of these materials may potentiate the pro-healing action of fetal membranes. Comparison of such materials with fetal membranes has been scant, and their combined use with fetal membranes has been underexplored. This review presents an up-to-date overview of (i) clinical applications of human fetal membranes in wound healing and tissue regeneration; (ii) studies comparing human fetal membranes with natural materials for promoting wound healing; and (iii) the literature on the combined use of fetal membranes and natural pro-healing materials.
人胎膜是一种全球认可的生物生物材料，可用于包括皮肤科、眼科以及最近的骨科、颌面和口腔外科以及神经再生等多个领域的伤口和组织修复与再生。羊膜和胎盘的细胞和基质成分都有好处，会释放出多种生长因子、细胞因子、肽和可溶性细胞外基质成分。除了胎膜，还有许多天然材料也被报道具有促进伤口愈合的作用。这些材料的生物学特性可能增强胎膜的促愈合作用。与胎膜相比，这些材料的比较研究很少，它们与胎膜联合使用的研究也很少。本综述介绍了（i）人胎膜在伤口愈合和组织再生中的临床应用；（ii）比较人胎膜与天然材料促进伤口愈合的研究；以及（iii）关于胎膜与天然促愈合材料联合使用的文献。
