Biologie de la Reproduction, Hôpital Arnaud de Villeneuve, 34295 Montpellier, France.
INSERM DEFE, Université de Montpellier, 34090 Montpellier, France.
Int J Mol Sci. 2024 Nov 7;25(22):11981. doi: 10.3390/ijms252211981.
Infertility, defined as the inability to obtain pregnancy after 12 months of regular unprotected sexual intercourse, has increased in prevalence over the past decades, similarly to chronic, allergic, autoimmune, or neurodegenerative diseases. A recent ARIA-MeDALL hypothesis has proposed that all these diseases are linked to dysbiosis and to some cytokines such as interleukin 17 (IL-17) and interleukin 33 (IL-33). Our paper suggests that endometriosis, a leading cause of infertility, is linked to endometrial dysbiosis and two key cytokines, IL-17 and IL-33, which interact with intestinal dysbiosis. Intestinal dysbiosis contributes to elevated estrogen levels, a primary factor in endometriosis. Estrogens strongly activate IL-17 and IL-33, supporting the existence of a gut-endometrial axis as a significant contributor to infertility.
不孕，定义为在 12 个月的正常无保护性行为后无法怀孕，在过去几十年中患病率有所增加，类似于慢性、过敏、自身免疫或神经退行性疾病。最近的 ARIA-MeDALL 假说提出，所有这些疾病都与肠道菌群失调和某些细胞因子如白细胞介素 17（IL-17）和白细胞介素 33（IL-33）有关。我们的论文表明，子宫内膜异位症是不孕的主要原因，与子宫内膜菌群失调和两种关键细胞因子白细胞介素 17（IL-17）和白细胞介素 33（IL-33）有关，它们与肠道菌群失调相互作用。肠道菌群失调导致雌激素水平升高，这是子宫内膜异位症的一个主要因素。雌激素强烈激活白细胞介素 17（IL-17）和白细胞介素 33（IL-33），支持肠道-子宫内膜轴作为导致不孕的一个重要因素的存在。
