Metabolic Health and Muscle Physiology Laboratory, Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA.
Mitochondrial Biology and Endurance Trainability Laboratory, Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA.
Int J Mol Sci. 2024 Nov 15;25(22):12280. doi: 10.3390/ijms252212280.
Bioenergetic pathways uniquely support sarcomere function which, in turn, helps to maintain functional skeletal muscle (SKM) mass. Emerging evidence supports alcohol (EtOH)-induced bioenergetic impairments in SKM and muscle precursor cells. We performed a scoping review to synthesize existing evidence regarding the effects of EtOH on SKM bioenergetics. Eligible articles from six databases were identified, and titles, abstracts, and full texts for potentially relevant articles were screened against inclusion criteria. Through the search, we identified 555 unique articles, and 21 met inclusion criteria. Three studies investigated EtOH effects on the adenosine triphosphate (ATP)-phosphocreatine (PCr) system, twelve investigated EtOH effects on glycolytic metabolism, and seventeen investigated EtOH effects on mitochondrial metabolism. Despite increased ATP-PCr system reliance, EtOH led to an overall decrease in bioenergetic function through decreased expression and activity of glycolytic and mitochondrial pathway components. However, effects varied depending on the EtOH dose and duration, model system, and sample type. The results detail the EtOH-induced shifts in energy metabolism, which may adversely affect sarcomere function and contribute to myopathy. These findings should be used to develop targeted interventions that improve SKM bioenergetic function, and thus sarcomere function, in people with Alcohol Use Disorder (AUD). Key areas in need of further investigation are also identified.
生物能量途径独特地支持肌节功能，而肌节功能又有助于维持功能性骨骼肌 (SKM) 质量。新出现的证据支持酒精 (EtOH) 对 SKM 和肌肉前体细胞的生物能量损伤。我们进行了范围综述，以综合现有的关于 EtOH 对 SKM 生物能量学影响的证据。从六个数据库中确定了符合条件的文章，并根据纳入标准筛选了可能相关文章的标题、摘要和全文。通过搜索，我们确定了 555 篇独特的文章，其中 21 篇符合纳入标准。三项研究调查了 EtOH 对三磷酸腺苷 (ATP)-磷酸肌酸 (PCr) 系统的影响，十二项研究调查了 EtOH 对糖酵解代谢的影响，十七项研究调查了 EtOH 对线粒体代谢的影响。尽管增加了 ATP-PCr 系统的依赖，但 EtOH 通过降低糖酵解和线粒体途径成分的表达和活性，导致生物能量功能总体下降。然而，影响因 EtOH 剂量和持续时间、模型系统和样本类型而异。这些结果详细说明了能量代谢中 EtOH 引起的变化，这可能会对肌节功能产生不利影响，并导致肌病。这些发现应被用于开发有针对性的干预措施，以改善患有酒精使用障碍 (AUD) 的人的 SKM 生物能量功能，从而改善肌节功能。还确定了需要进一步研究的关键领域。
