Banerji Aabir, Brinkman Nichole E, Davis Benjamin, Franklin Alison, Jahne Michael, Keely Scott P
US Environmental Protection Agency, Office of Research and Development, Duluth, MN 55804, USA.
US Environmental Protection Agency, Office of Research and Development, Cincinnati, OH 45268, USA.
Microorganisms. 2024 Oct 23;12(11):2121. doi: 10.3390/microorganisms12112121.
Antimicrobial resistance (AMR) has long been framed as an epidemiological and public health concern. Its impacts on the environment are unclear. Yet, the basis for AMR is altered cell physiology. Just as this affects how microbes interact with antimicrobials, it can also affect how they interact with their own species, other species, and their non-living environment. Moreover, if the microbes are globally notorious for causing landscape-level environmental issues, then these effects could alter biodiversity and ecosystem function on a grand scale. To investigate these possibilities, we compiled peer-reviewed literature from the past 20 years regarding AMR in toxic freshwater cyanobacterial harmful algal blooms (HABs). We examined it for evidence of AMR affecting HAB frequency, severity, or persistence. Although no study within our scope was explicitly designed to address the question, multiple studies reported AMR-associated changes in HAB-forming cyanobacteria (and co-occurring microbes) that pertained directly to HAB timing, toxicity, and phase, as well as to the dynamics of HAB-afflicted aquatic food webs. These findings highlight the potential for AMR to have far-reaching environmental impacts (including the loss of biodiversity and ecosystem function) and bring into focus the importance of confronting complex interrelated issues such as AMR and HABs in concert, with interdisciplinary tools and perspectives.
长期以来，抗生素耐药性（AMR）一直被视为一个流行病学和公共卫生问题。其对环境的影响尚不清楚。然而，AMR的基础是细胞生理学的改变。正如这会影响微生物与抗生素的相互作用一样，它也会影响微生物与自身物种、其他物种以及非生物环境的相互作用。此外，如果这些微生物因引发景观层面的环境问题而在全球臭名昭著，那么这些影响可能会大规模改变生物多样性和生态系统功能。为了探究这些可能性，我们收集了过去20年中关于有毒淡水蓝藻有害藻华（HABs）中AMR的同行评审文献。我们检查这些文献，以寻找AMR影响HAB频率、严重程度或持续时间的证据。尽管我们范围内没有一项研究是专门设计来解决这个问题的，但多项研究报告了与AMR相关的形成HAB的蓝藻（以及共生微生物）的变化，这些变化直接与HAB的时间、毒性和阶段有关，也与受HAB影响的水生食物网的动态有关。这些发现凸显了AMR产生深远环境影响（包括生物多样性丧失和生态系统功能丧失）的可能性，并使人们更加关注协同应对AMR和HAB等复杂相互关联问题的重要性，需要运用跨学科工具和视角。
