眼部微生物群：靶向治疗向宏观转变的微小步骤？一项综述。
The Ocular Microbiome: Micro-Steps Towards Macro-Shift in Targeted Treatment? A Comprehensive Review.
作者信息
Trojacka Ewelina, Izdebska Justyna, Szaflik Jacek, Przybek-Skrzypecka J
机构信息
SPKSO Ophthalmic University Hospital in Warsaw, 03-709 Warsaw, Poland.
Department of Ophthalmology, Medical University of Warsaw, 03-709 Warsaw, Poland.
出版信息
Microorganisms. 2024 Nov 4;12(11):2232. doi: 10.3390/microorganisms12112232.
A healthy ocular surface is inhabited by microorganisms that constitute the ocular microbiome. The core of the ocular microbiome is still a subject of debate. Numerous culture-dependent and gene sequencing studies have revealed the composition of the ocular microbiome. There was a confirmed correlation between the ocular microbiome and ocular surface homeostasis as well as between ocular dysbiosis and pathologies such as blepharitis, microbial keratitis, and conjunctivitis. However, the role of the ocular microbiome in the pathogenesis and treatment of ocular surface diseases remains unclear. This article reviews available data on the ocular microbiome and microbiota, their role in maintaining ocular homeostasis, and the impact of dysbiosis on several ophthalmic disorders. Moreover, we aimed to discuss potential treatment targets within the ocular microbiota.
健康的眼表存在着构成眼微生物群的微生物。眼微生物群的核心仍是一个有争议的话题。众多依赖培养和基因测序的研究揭示了眼微生物群的组成。眼微生物群与眼表稳态之间以及眼生态失调与睑缘炎、微生物性角膜炎和结膜炎等病症之间存在已证实的相关性。然而，眼微生物群在眼表疾病的发病机制和治疗中的作用仍不清楚。本文综述了关于眼微生物群和微生物群落的现有数据、它们在维持眼内稳态中的作用以及生态失调对几种眼科疾病的影响。此外，我们旨在讨论眼微生物群落中的潜在治疗靶点。
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