Karaca Yücel, Karasu Mehdi, Gelen Mehmet Ali, Şahin Şeyda, Yavçin Özkan, Yaman İrfan, Hidayet Şıho
Department of Cardiology, Fethi Sekin Sehir Hastanesi, 23280 Elazıg, Turkey.
Department of Cardiology, Gaziantep Şehir Hastanesi, 27470 Gaziantep, Turkey.
J Clin Med. 2024 Nov 6;13(22):6647. doi: 10.3390/jcm13226647.
Accumulating evidence from clinical trials, large registries, and meta-analyses of population studies shows that increased Blood Pressure Variability (BPV) is predictive of Cardiovascular (CV) outcomes, independently of the average Blood Pressure (BP) values. One of the mechanisms explaining the relationship between BPV and target organ damage is the inflammatory response. The Systemic Immune Inflammation Index (SII), which relies on peripheral blood cell counts, including platelets, neutrophils, and lymphocytes, has emerged as a predictor of prognosis and outcomes in various diseases. The aim of this study was to investigate the association of the SII with Ambulatory Blood Pressure Variability (ABPV) in newly diagnosed hypertensive patients. This study was designed as a cross-sectional observational study. A total of 1606 consecutive newly diagnosed Hypertension (HT) patients were included in the study. The population was evaluated across 3 different categories according to HT grades (5 groups), eligibility for antihypertensive therapy (2 groups) and ABPV levels (2 groups). Significant differences were observed between ABPV groups in terms of Neutrophil to Lymphocyte ratio, Platelet to Lymphocyte ratio, glucose, SII, high-sensitive CRP, HT grade, Inter-Ventricular Septum, Posterior Wall thickness, and Left Ventricular Mass ( < 0.005). There was a significant relationship between SII and ABPV (r: 0.619, < 0.05). At the cutoff value of 580.49, SII had 77% sensitivity and 71% specificity for ABPV > 14 (AUC: 0.788). SII may assist in developing an early treatment approach to minimize complications in patients with high ABPV who are at a higher risk of CV events.
来自临床试验、大型登记研究和人群研究的荟萃分析的越来越多的证据表明，血压变异性（BPV）增加可预测心血管（CV）结局，且独立于平均血压（BP）值。解释BPV与靶器官损害之间关系的机制之一是炎症反应。全身免疫炎症指数（SII）依赖于外周血细胞计数，包括血小板、中性粒细胞和淋巴细胞，已成为各种疾病预后和结局的预测指标。本研究的目的是调查新诊断高血压患者中SII与动态血压变异性（ABPV）的关联。 本研究设计为横断面观察性研究。共有1606例连续新诊断的高血压（HT）患者纳入研究。根据HT分级（5组）、降压治疗 eligibility（2组）和ABPV水平（2组）将人群分为3个不同类别进行评估。 在ABPV组之间，中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、血糖、SII、高敏CRP、HT分级、室间隔、后壁厚度和左心室质量方面观察到显著差异（<0.005）。SII与ABPV之间存在显著关系（r：0.619，<0.05）。在临界值580.49时，SII对ABPV>14的敏感性为77%，特异性为71%（AUC：0.788）。SII可能有助于制定早期治疗方法，以尽量减少ABPV高且CV事件风险较高的患者的并发症。
