Hayat Umar, Kamal Faisal, Kamal Muhammad U, Mirza Wasique, Ahmad Tariq A, Gangwani Manesh K, Dahiya Dushyant S, Ali Hassam, Naidoo Shiva F, Humayun Sara, Okut Hayrettin, Aziz Muhammad
Department of Internal Medicine, Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA 18705, USA.
Department of Internal Medicine, Division of Gastroenterology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
J Clin Med. 2024 Nov 18;13(22):6946. doi: 10.3390/jcm13226946.
Non-alcoholic liver disease (NAFLD) may be associated with cardiovascular diseases; however, only a few studies have analyzed this relationship. We aimed to assess the epidemiologic data and the association between NAFLD and acute myocardial infarction (AMI) in the United States. The National Inpatient Sample (NIS) database 2016-2019 was queried using ICD10-CM diagnostic codes to identify hospitalizations of AMI + NAFLD. Essential demographic variables were analyzed to determine the disparities in the prevalence of AMI hospitalizations and deaths among NAFLD patients. Univariate and multivariate logistic regression models determined the association between NAFLD and AMI hospitalizations and death. Among the total 5450 NAFLD patients hospitalized with AMI, 5.11% (279) died. Females were less likely to be admitted and die due to AMI than males. Younger patients (<50) were less likely to be hospitalized and die than those ≥50. Compared to the white population, black patients were less likely; however, Hispanics, Asians, and Pacific Islanders were more likely to be hospitalized. Race was not found to affect hospital mortality. On multivariate analysis, NAFLD was associated with higher odds of AMI hospitalization [OR 1.55, 95% CI 1.51-1.60, < 0.01] and death [OR 1.96, 95% CI 1.74-2.21, < 0.01]. Older white males with NAFLD had a higher prevalence of AMI hospitalizations and mortality.
非酒精性肝病（NAFLD）可能与心血管疾病有关；然而，仅有少数研究分析了这种关系。我们旨在评估美国NAFLD与急性心肌梗死（AMI）之间的流行病学数据及关联。使用ICD10-CM诊断编码查询2016 - 2019年国家住院患者样本（NIS）数据库，以识别AMI + NAFLD的住院病例。分析基本人口统计学变量，以确定NAFLD患者中AMI住院率和死亡率的差异。单因素和多因素逻辑回归模型确定NAFLD与AMI住院及死亡之间的关联。在总共5450例因AMI住院的NAFLD患者中，5.11%（279例）死亡。女性因AMI入院和死亡的可能性低于男性。年龄较小的患者（<50岁）住院和死亡的可能性低于年龄≥50岁的患者。与白人相比，黑人患者住院的可能性较小；然而，西班牙裔、亚裔和太平洋岛民住院的可能性更大。未发现种族影响医院死亡率。多因素分析显示，NAFLD与AMI住院几率较高相关[比值比（OR）1.55，95%置信区间（CI）1.51 - 1.60，P < 0.01]以及死亡相关[OR 1.96，95% CI 1.74 - 2.21，P < 0.01]。患有NAFLD的老年白人男性AMI住院率和死亡率较高。
