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《槐属异戊烯基联苯酸及其衍生物作为多治疗药物的研究进展：全面综述》

Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review.

机构信息

Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China.

School of Rehabilitation, Gannan Medical University, Ganzhou 341000, China.

出版信息

Molecules. 2024 Nov 18;29(22):5440. doi: 10.3390/molecules29225440.

DOI:10.3390/molecules29225440
PMID:39598829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11597117/
Abstract

Pigeon pea ( (L.) Millsp.) is a traditional Chinese medicinal plant widely utilized in folk medicine due to its significant pharmacological and nutritional properties. Cajaninstilbene acid (CSA), a stilbene compound derived from pigeon pea leaves, has been extensively investigated since the 1980s. A thorough understanding of CSA's mechanisms of action and its therapeutic effects on various diseases is crucial for developing novel therapeutic approaches. This paper presents an overview of recent research advancements concerning the biological activities and mechanisms of CSA and its derivatives up to February 2024. The review encompasses discussions on the in vivo metabolism of CSA and its derivatives, including antipathogenic micro-organisms activity, anti-tumor activity, systematic and organ protection activity (such as bone protection, cardiovascular protection, neuroprotection), anti-inflammatory activity, antioxidant activity, immune regulation as well as action mechanism of CSA and its derivatives. The most studied activities are antipathogenic micro-organisms activities. Additionally, the structure-activity relationships of CSA and its derivatives as well as the total synthesis of CSA are explored, highlighting the potential for developing new pharmaceutical agents. This review aims to provide a foundation for future clinical applications of CSA and its derivatives.

摘要

兵豆（（L.）Millsp.）是一种传统的中草药，由于其具有显著的药理和营养特性，在民间医学中被广泛应用。自从 20 世纪 80 年代以来，来源于兵豆叶子的芪类化合物兵豆素 A（CSA）已经得到了广泛的研究。深入了解 CSA 的作用机制及其对各种疾病的治疗效果对于开发新的治疗方法至关重要。本文综述了截至 2024 年 2 月 CSA 及其衍生物的生物学活性和作用机制的最新研究进展。综述内容包括 CSA 及其衍生物的体内代谢以及它们的抗病原微生物活性、抗肿瘤活性、系统和器官保护活性（如骨保护、心血管保护、神经保护）、抗炎活性、抗氧化活性、免疫调节作用以及 CSA 及其衍生物的作用机制。研究最多的活性是抗病原微生物活性。此外，还探讨了 CSA 及其衍生物的结构-活性关系以及 CSA 的全合成，强调了开发新药物制剂的潜力。本文旨在为 CSA 及其衍生物的未来临床应用提供基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/43c63734c403/molecules-29-05440-sch009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/55ceef1d6798/molecules-29-05440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/b85b90e74ec7/molecules-29-05440-sch001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/fe84d2cf48a8/molecules-29-05440-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/18660321f362/molecules-29-05440-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/d8aa83ca749a/molecules-29-05440-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/ac065e2892ed/molecules-29-05440-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/3df2e2c91ffb/molecules-29-05440-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/25fcb1e9fcc6/molecules-29-05440-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/43746a888ac0/molecules-29-05440-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/dc9016716167/molecules-29-05440-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/ef08cf043a49/molecules-29-05440-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/36b9418e86b5/molecules-29-05440-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2143/11597117/43c63734c403/molecules-29-05440-sch009.jpg

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