Huang Wenlin, Wang Xu, Zhao Zhenyu
College of Science, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Adv Healthc Mater. 2025 Jan;14(3):e2402935. doi: 10.1002/adhm.202402935. Epub 2024 Nov 26.
Mg (Magnesium ion) can affect bone tissue metabolism by regulating related signaling pathways in bone metabolism. However, how to realize precise controlled release of Mg in bone regeneration treatment still presents a challenge. Herein, for the first time, the GelMA-BP (Gelatin Methacryloyl-Bisphosphonate) and the composite nano-bubble system are fused to construct the Mg blasting controlled-release hydrogel microspheres, the stability of the nano-bubbles in the microspheres is enhanced through metal coordination complexation, and the burst of the nano-bubbles is controlled by using ultrasonic cavitation to achieve the precise controlled release of Mg, ultimately effectively promoting bone reconstruction. First, GelMA-BP composite is prepared by Schiff base reaction. Second, the nanobubble BP (Bisphosphonate) system is constructed, and Mg is combined with the ligand coordination to prepare the composite nanobubble system. Thirdly, through Mg co-coordination, the ultrasound-triggered Mg blasting controlled release microspheres were prepared to achieve bone repair. Overall, this innovative strategy effectively solves the problem of accurate controlled release of Mg, and finally effectively activates in situ bone tissue regeneration.
镁离子（Mg）可通过调节骨代谢中的相关信号通路来影响骨组织代谢。然而，在骨再生治疗中如何实现镁的精确控释仍是一个挑战。在此，首次将甲基丙烯酰化明胶-双膦酸盐（GelMA-BP）与复合纳米气泡系统融合，构建镁爆破控释水凝胶微球，通过金属配位络合增强微球中纳米气泡的稳定性，并利用超声空化控制纳米气泡的破裂以实现镁的精确控释，最终有效促进骨重建。首先，通过席夫碱反应制备GelMA-BP复合材料。其次，构建纳米气泡双膦酸盐（BP）系统，并将镁与配体配位结合以制备复合纳米气泡系统。第三，通过镁的共配位作用，制备超声触发的镁爆破控释微球以实现骨修复。总体而言，这种创新策略有效解决了镁的精确控释问题，并最终有效激活原位骨组织再生。
