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Fragmented thrombi, targeted solutions: Exploring GPVI inhibition in high-shear environments.

作者信息

Rabinowitz Edon J, Bark David

机构信息

Divisions of Pediatric Cardiology & Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri.

Pediatric Hematology Oncology, Biomedical Engineering, Division of Biology and Biomedical Sciences, Washington University School of Medicine in St. Louis, St. Louis, Missouri.

出版信息

Biophys J. 2025 Jan 7;124(1):6-7. doi: 10.1016/j.bpj.2024.11.3309. Epub 2024 Nov 26.

DOI:10.1016/j.bpj.2024.11.3309
PMID:39600092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11739869/
Abstract
摘要

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GPVI-mediated thrombus stabilization of shear-induced platelet aggregates in a microfluidic stenosis.糖蛋白VI介导的微流控狭窄中剪切诱导血小板聚集体的血栓稳定作用。
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Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies.二聚体GPVI-Fc和抗GPVI抗体对人动脉粥样硬化斑块诱导的血小板活化的差异性抑制：功能与成像研究
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Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation.抗 GpVI 纳米抗体阻断胶原和动脉粥样硬化斑块诱导的 GpVI 聚集、信号转导和血栓形成。
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本文引用的文献

1
GPVI-mediated thrombus stabilization of shear-induced platelet aggregates in a microfluidic stenosis.糖蛋白VI介导的微流控狭窄中剪切诱导血小板聚集体的血栓稳定作用。
Biophys J. 2025 Jan 7;124(1):158-171. doi: 10.1016/j.bpj.2024.11.018. Epub 2024 Nov 22.
2
Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging.多参数血栓形成分析微流控技术检测与高血压和衰老相关的增强的生物力学血栓形成。
Nat Commun. 2024 Oct 21;15(1):9067. doi: 10.1038/s41467-024-53069-9.
3
Distinct platelet F-actin patterns and traction forces on von Willebrand factor versus fibrinogen.血小板 F-actin 模式和对 von Willebrand 因子与纤维蛋白原的牵引力有明显差异。
Biophys J. 2023 Sep 19;122(18):3738-3748. doi: 10.1016/j.bpj.2023.07.006. Epub 2023 Jul 10.
4
Glycoprotein VI interplay with fibrin(ogen) in thrombosis.糖蛋白 VI 与纤维蛋白原（原）在血栓形成中的相互作用。
J Thromb Haemost. 2023 Jul;21(7):1703-1713. doi: 10.1016/j.jtha.2023.03.022. Epub 2023 Mar 28.
5
Investigating thrombin-loaded fibrin in whole blood clot microfluidic assay via fluorogenic peptide.通过荧光肽研究全血凝块微流控分析中的载凝血酶纤维蛋白
Biophys J. 2023 Feb 21;122(4):697-712. doi: 10.1016/j.bpj.2023.01.008. Epub 2023 Jan 12.
6
Dual antiplatelet therapy in patients at high bleeding risk: less is more-more or less.高出血风险患者的双重抗血小板治疗：少即是多——还是并非如此。
Eur Heart J. 2023 Mar 14;44(11):969-971. doi: 10.1093/eurheartj/ehac713.
7
Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation.抗 GpVI 纳米抗体阻断胶原和动脉粥样硬化斑块诱导的 GpVI 聚集、信号转导和血栓形成。
J Thromb Haemost. 2022 Nov;20(11):2617-2631. doi: 10.1111/jth.15836. Epub 2022 Aug 12.
8
Flow studies on human GPVI-deficient blood under coagulating and noncoagulating conditions.在凝固和非凝固条件下对人 GPVI 缺陷血液进行流动研究。
Blood Adv. 2020 Jul 14;4(13):2953-2961. doi: 10.1182/bloodadvances.2020001761.
9
Validation of the Academic Research Consortium High Bleeding Risk Definition in Contemporary PCI Patients.当代经皮冠状动脉介入治疗患者中学术研究联盟高出血风险定义的验证。
J Am Coll Cardiol. 2020 Jun 2;75(21):2711-2722. doi: 10.1016/j.jacc.2020.03.070.
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Fibrin activates GPVI in human and mouse platelets.纤维蛋白激活人和小鼠血小板中的糖蛋白VI（GPVI）。
Blood. 2015 Sep 24;126(13):1601-8. doi: 10.1182/blood-2015-04-641654. Epub 2015 Aug 17.