Lack of DNA-strand breaks in rat testicular cells after in vivo treatment with sodium fluoride.
作者信息
Skare J A, Schrotel K R, Nixon G A
出版信息
Mutat Res. 1986 Apr-May;170(1-2):85-92. doi: 10.1016/0165-1218(86)90085-6.
PMID:3960046
Abstract
Oral administration of up to 84 mg/kg of NaF to adult male rats did not induce DNA-strand breaks in testicular cells when measured by alkaline elution. Although plasma fluoride levels were as high as 12 ppm is rats given 84 mg/kg of NaF, testicular fluoride levels in most cases were only 10-20% of plasma levels. Fluoride did not accumulate in the testes after 5 daily treatments. Therefore, it is unlikely that NaF, even at high doses, poses a hazard with respect to heritable genetic effects.
摘要
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