Liang Ming-Xing, Chen Ya, He Ya, He Yi-Huai
Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China.
World J Clin Cases. 2024 Nov 26;12(33):6608-6612. doi: 10.12998/wjcc.v12.i33.6608.
IgG4-related sclerosing cholangitis (IgG4-SC) is an inflammatory disease that leads to bile duct stricture, characterized by the infiltration of IgG4-positive plasma cells into the bile duct wall, thickening of the bile duct wall, and narrowing of the lumen. The differential diagnosis of IgG4-SC mainly includes primary sclerosing cholangitis, cholangiocarcinoma, and pancreatic cancer. IgG4-SC is often associated with autoimmune pancreatitis and can be accurately diagnosed based on clinical diagnostic criteria. However, isolated IgG4-SC is difficult to distinguish from biliary tumors. Given the significant differences in biological behavior, treatment, and prognosis between these diseases, accurately identifying isolated IgG4-SC has very important clinical significance.
IgG4相关性硬化性胆管炎（IgG4-SC）是一种导致胆管狭窄的炎症性疾病，其特征为IgG4阳性浆细胞浸润胆管壁、胆管壁增厚及管腔狭窄。IgG4-SC的鉴别诊断主要包括原发性硬化性胆管炎、胆管癌和胰腺癌。IgG4-SC常与自身免疫性胰腺炎相关，可根据临床诊断标准准确诊断。然而，孤立性IgG4-SC难以与胆管肿瘤相鉴别。鉴于这些疾病在生物学行为、治疗及预后方面存在显著差异，准确识别孤立性IgG4-SC具有非常重要的临床意义。
