病例报告：一例血培养阴性的心内膜炎：血液宏基因组二代测序是早期诊断的有效方法。

Case report: A case of blood culture-negative endocarditis: blood mNGS is an efficient method for early diagnosis.

作者信息

Pu Jun-Fan, Zhou Yan-Ling, Deng Min, Wu Jing

机构信息

Department of Infectious Disease, The People's Hospital of Dazu District, Chongqing, China.

The First Clinical College, Chongqing Medical University, Chongqing, China.

出版信息

Front Med (Lausanne). 2024 Nov 11;11:1449637. doi: 10.3389/fmed.2024.1449637. eCollection 2024.

DOI:10.3389/fmed.2024.1449637

PMID:39600931

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11589816/

Abstract

is one of the main causes of blood culture-negative endocarditis, and routine blood culture and serological methods are difficult to achieve early diagnosis. We report a case of blood culture-negative endocarditis from southwestern Chongqing. The patient was a 67-year-old male scavenger who presented with heart failure without fever as the main clinical manifestation upon admission. He stated having had contact with stray cats in the past 2 months. The combination of clinical symptoms, echocardiography, and blood mNGS testing confirmed the infection of .

摘要

是血培养阴性的心内膜炎的主要病因之一，常规血培养和血清学方法难以实现早期诊断。我们报告一例来自重庆西南部的血培养阴性的心内膜炎病例。患者是一名67岁的男性拾荒者，入院时以心力衰竭为主要临床表现，无发热。他称在过去2个月内接触过流浪猫。临床症状、超声心动图和血液宏基因组测序检测相结合确诊了……的感染。