Jiang Zhimeng, Jiang Huixin, Zhu Xingyu, Zhao Donglin, Su Feifei
Graduate School of Hebei North University, Zhangjiakou, China.
Department of Gastroenterology, Air Force Medical Center, Chinese People's Liberation Army, Beijing, China.
Front Med (Lausanne). 2024 Nov 12;11:1453129. doi: 10.3389/fmed.2024.1453129. eCollection 2024.
High-sensitivity C-reactive protein (hs-CRP), a classical indicator of inflammation, holds significant clinical value in various diseases. The relationship between hs-CRP and gallstones, however, remains poorly studied at present. The relationship between hs-CRP and gallstones will be investigated in this study.
Data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES) were analyzed, focusing on participants aged 20 years and older who provided complete hs-CRP and gallstone information. Due to the skewed distribution of hs-CRP, the data were log-transformed [Log (hs-CRP)] to achieve normalization. Logistic regression analysis, subgroup analysis, and smoothed fitted curves were applied to determine the relationship between Log (hs-CRP) and the presence of gallstones.
The study included 4,484 participants with an average Log (hs-CRP) of 1.18 ± 0.74. The prevalence of gallstones was 11.15%, increasing with higher Log (hs-CRP) levels (quartile 1: 8.31%; quartile 2: 8.76%; quartile 3: 11.98%; quartile 4: 16.36%; < 0.0001). Adjusting for all covariates in Model 3, each 10-fold increase in hs-CRP [corresponding to a one-unit increase in log10 (hs-CRP)] corresponded to a 29% increased odds of gallstones prevalence [1.29 (1.12-1.49)]. The smoothed fitted curve showed a positive linear relationship between Log (hs-CRP) and gallstones prevalence. The results of subgroup analyses exhibited a more pronounced positive correlation in the 20-40 age group [1.70 (1.33, 2.16)], compared to those aged 40-60 years [1.22 (1.01, 1.48)], and 60-80 years [1.14 (0.98, 1.34)].
Higher Log (hs-CRP) levels are linked to a greater prevalence of gallstones. We still need to carry out further large prospective research to explore the causal relationship of this association.
高敏C反应蛋白（hs-CRP）是一种经典的炎症指标，在多种疾病中具有重要的临床价值。然而，目前关于hs-CRP与胆结石之间的关系研究较少。本研究将对hs-CRP与胆结石之间的关系进行调查。
分析了2017 - 2020年美国国家健康与营养检查调查（NHANES）的数据，重点关注20岁及以上提供了完整hs-CRP和胆结石信息的参与者。由于hs-CRP数据呈偏态分布，对数据进行对数转换[Log(hs-CRP)]以实现正态化。应用逻辑回归分析、亚组分析和平滑拟合曲线来确定Log(hs-CRP)与胆结石存在之间的关系。
该研究纳入了4484名参与者，平均Log(hs-CRP)为1.18±0.74。胆结石的患病率为11.15%，随着Log(hs-CRP)水平的升高而增加（四分位数1：8.31%；四分位数2：8.76%；四分位数3：11.98%；四分位数4：16.36%；P<0.0001）。在模型3中对所有协变量进行调整后，hs-CRP每增加10倍[对应于log10(hs-CRP)增加一个单位]，胆结石患病率的比值增加29%[1.29(1.12 - 1.49)]。平滑拟合曲线显示Log(hs-CRP)与胆结石患病率之间呈正线性关系。亚组分析结果显示，与40 - 60岁[1.22(1.01, 1.48)]和60 - 80岁[1.14(0.98, 1.34)]的人群相比，20 - 40岁年龄组[1.70(1.33, 2.16)]的正相关性更为明显。
较高的Log(hs-CRP)水平与更高的胆结石患病率相关。我们仍需开展进一步的大型前瞻性研究，以探索这种关联的因果关系。
