Li Meng, Zhang Lisong, Li Xiaoyu, Yan Weisheng
Department of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.
Front Endocrinol (Lausanne). 2024 Nov 12;15:1474738. doi: 10.3389/fendo.2024.1474738. eCollection 2024.
Insulin resistance (IR) can lead to infertility in women. The primary objective of this research was to examine how estimated glucose disposal rate (eGDR) correlates with infertility in women, assessing its validity as an indicator of IR.
Data from the National Health and Nutrition Examination Survey spanning 2013 to 2018 were analyzed in this study. In order to investigate the correlation between eGDR and the prevalence of female infertility, this study used a combination of weighted multivariate regression analysis, restricted cubic spline (RCS) analysis, subgroup analyses, sensitive analysis, and receiver operating characteristic (ROC) curves.
This study enrolled 2541 women, with an average age of (32.52 ± 0.23) years. The overall infertility rate was 14.27%. A negative relationship was observed between eGDR levels and female infertility. Each increment of one unit in eGDR was linked to a 14% reduction in infertility incidence (OR = 0.86, 95% CI 0.80-0.94). RCS analysis revealed a nonlinear, inverse correlation between eGDR and female infertility. Subgroup analyses indicated that age influenced the association between eGDR and female infertility. The ROC curve suggested that eGDR was significantly better than HOMA-IR in predicting infertility [eGDR: 0.632 (95% CI: 0.603, 0.660) vs. HOMA-IR: 0.543 (95% CI: 0.514, 0.572)].
There was an observed association where lower eGDR levels were linked with higher rates of female infertility. These results emphasize the significance of implementing measures to manage IR to protect women's reproductive health.
胰岛素抵抗（IR）可导致女性不孕。本研究的主要目的是探讨估计葡萄糖处置率（eGDR）与女性不孕之间的相关性，并评估其作为IR指标的有效性。
本研究分析了2013年至2018年美国国家健康与营养检查调查的数据。为了研究eGDR与女性不孕患病率之间的相关性，本研究采用了加权多元回归分析、受限立方样条（RCS）分析、亚组分析、敏感性分析和受试者工作特征（ROC）曲线等方法。
本研究纳入了2541名女性，平均年龄为（32.52±0.23）岁。总体不孕率为14.27%。观察到eGDR水平与女性不孕之间呈负相关。eGDR每增加一个单位，不孕发生率降低14%（OR=0.86，95%CI 0.80-0.94）。RCS分析显示eGDR与女性不孕之间存在非线性负相关。亚组分析表明年龄影响eGDR与女性不孕之间的关联。ROC曲线表明，在预测不孕方面，eGDR显著优于稳态模型评估的胰岛素抵抗（HOMA-IR）[eGDR：0.632（95%CI：0.603，0.660）vs.HOMA-IR：0.543（95%CI：0.514，0.572）]。
观察到eGDR水平较低与女性不孕率较高之间存在关联。这些结果强调了采取措施管理IR以保护女性生殖健康的重要性。
