Yan Lingli, Xu Kunyao, Liu Chaoyong, Yu Feng, Guo Jimin, Hou Lihua, Feng Yicheng, Yang Mo, Gong Qihai, Qin Dajiang, Qin Meng, Wang Yilong, Su Huanxing, Lu Yunfeng
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Adv Mater. 2025 Jan;37(3):e2412843. doi: 10.1002/adma.202412843. Epub 2024 Nov 27.
Cerebral microinfarcts represent the most prevalent form of ischemic brain injury in the elderly, particularly among those suffering from dementia, Alzheimer's disease, and vascular risk factors. Despite their commonality, effective treatments have remained elusive. Herein, a novel treatment utilizing a polymer-formulated nerve growth factor capable of crossing the blood-brain barrier is reported, which effectively reduced oxidative stress and neuronal apoptosis, reshaped microglia polarization at infarct sites, and decreased the overall microinfarct burden, leading to notable improvements in behavioral and cognitive functions in a mouse model. This work provides a promising new avenue for the treatment of cerebral microinfarcts and other neurodegenerative diseases.
脑微梗死是老年人缺血性脑损伤最常见的形式，尤其是在患有痴呆症、阿尔茨海默病和血管危险因素的人群中。尽管它们很常见，但有效的治疗方法仍然难以捉摸。在此，报道了一种利用能够穿越血脑屏障的聚合物配方神经生长因子的新型治疗方法，该方法有效降低了氧化应激和神经元凋亡，重塑了梗死部位的小胶质细胞极化，并减轻了整体脑微梗死负担，从而使小鼠模型的行为和认知功能得到显著改善。这项工作为脑微梗死和其他神经退行性疾病的治疗提供了一条有前景的新途径。
