国际抗癫痫联盟新生儿癫痫框架有助于确定病因。
ILAE neonatal seizure framework to aide in determining etiology.
作者信息
Yozawitz Elissa G, Cilio Maria Roberta, Mizrahi Eli M, Moon Jee-Young, Moshé Solomon L, Nunes Magda L, Plouin Perrine, Zuberi Sameer, Pressler Ronit M
机构信息
Isabelle Rapin Division of Child Neurology of the Saul R. Korey Department of Neurology and Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
Department of Pediatrics Saint Luc University Hospital, and Institute of Neuroscience (IoNS), Catholic University of Louvain, Brussels, Belgium.
出版信息
Epileptic Disord. 2025 Feb;27(1):64-70. doi: 10.1002/epd2.20312. Epub 2024 Nov 27.
OBJECTIVE
To employ the neonatal seizure framework developed by the International League Against Epilepsy (ILAE) Neonatal Task force to assess its usefulness in determining the etiology of neonatal seizures.
METHODS
The members of the ILAE Neonatal Task Force evaluated 157 seizures from 146 neonates to determine internal validity and associations between semiology and a specific etiology.
RESULTS
Provoked neonatal electrographic and electroclinical seizures were due to multiple etiologies. For electroclinical seizures, unilateral clonic seizures were typically seen with vascular etiologies, focal tonic seizures and sequential seizures with genetic etiologies, and myoclonic seizures with inborn errors of metabolism. Electrographic seizures were often seen in hypoxic-ischemic encephalopathy or vascular etiologies.
SIGNIFICANCE
These data suggest that the ILAE neonatal seizure classification may be used as a bedside tool to aid and guide workup to determine the etiology of seizures.
目的
应用国际抗癫痫联盟（ILAE）新生儿工作组制定的新生儿癫痫框架，评估其在确定新生儿癫痫病因方面的实用性。
方法
ILAE新生儿工作组的成员评估了146例新生儿的157次癫痫发作，以确定内部效度以及症状学与特定病因之间的关联。
结果
诱发性新生儿脑电图和电临床发作由多种病因引起。对于电临床发作，单侧阵挛性发作通常见于血管性病因，局灶性强直性发作和连续性发作见于遗传性病因，肌阵挛性发作见于先天性代谢异常。脑电图发作常见于缺氧缺血性脑病或血管性病因。
意义
这些数据表明，ILAE新生儿癫痫分类可作为一种床边工具，辅助并指导检查以确定癫痫发作的病因。
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