Koo H S, Wu H M, Crothers D M
Nature. 1986;320(6062):501-6. doi: 10.1038/320501a0.
Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA . dT which are at least 4 base pairs long; the A . T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A . T tract and adjacent B-DNA, with a larger angle at the 3' than at the 5' end of the A tract.
DNA分子的固有弯曲源于至少4个碱基对长的同聚dA.dT区域中的局部结构多态性;A.T序列必须与螺旋螺距同相重复。弯曲发生在A.T序列与相邻B-DNA的连接处,其方向是碱基对倾斜而非滚动方向,在A序列的3'端比5'端的角度更大。