Chen Fushan, Cao Zhu, Zhu Chen
Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study, and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Chem Commun (Camb). 2024 Dec 12;60(100):14912-14923. doi: 10.1039/d4cc05739b.
The application of rearrangement reactions offers opportunities for the efficient construction of complex molecules that are challenging to obtain through conventional synthetic methods. However, the development of radical-mediated rearrangements has lagged far behind that of ionic-type rearrangements, due to the uncontrollability of radical species. Along with the recent renaissance in radical chemistry, radical-mediated functional group migration (FGM) reactions provide a versatile platform for the selective incorporation of functional groups across different molecular distances, enabling the construction of intricate molecular architectures. In the past few years, FGM reactions have showcased plentiful reaction modes, rendering precious control in terms of chemo- and regio-selectivities. This feature article summarizes our achievements in radical-mediated FGM reactions, wherein brief discussion of related works from other laboratories is also included. In this feature article, we aim to provide a comprehensive understanding of the progress in this emerging area.
重排反应的应用为高效构建复杂分子提供了机会，而这些复杂分子通过传统合成方法难以获得。然而，由于自由基物种的不可控性，自由基介导的重排反应的发展远远落后于离子型重排反应。随着近年来自由基化学的复兴，自由基介导的官能团迁移（FGM）反应提供了一个通用平台，用于在不同分子距离上选择性引入官能团，从而能够构建复杂的分子结构。在过去几年中，FGM反应展示了丰富的反应模式，在化学选择性和区域选择性方面实现了宝贵的控制。这篇专题文章总结了我们在自由基介导的FGM反应方面的成果，其中还包括对其他实验室相关工作的简要讨论。在这篇专题文章中，我们旨在全面了解这一新兴领域的进展。
