Moreno-Palacios Jorge, Maldonado-Alcaraz Efraín, Rivas-Ruiz Rodolfo, Vega-Hermosillo Romina, López-Sámano Virgilio Augusto
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Urología. Ciudad de México, México.
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Coordinación de Investigación en Salud, Centro de Adiestramiento en Investigación Clínica. Ciudad de México, México.
Rev Med Inst Mex Seguro Soc. 2024 Sep 5;62(suppl 2):1-8. doi: 10.5281/zenodo.10814377.
Percutaneous nephrolithotomy (PNL) is the first line treatment for kidney stones with a diameter > 2 cm. The available scores for measuring success in this procedure only consider the free stone status, without considering the complications.
To present a new prognostic stratification system to predict treatment failure in PNL.
Historic cohort in which prognostic factors and failure as residual stone with or without complication were identified. A bivariate analysis was performed using the numeric variables and with the use of conjunctive consolidation a prognostic stratification system was developed.
A total of 595 cases were included, out of which 73% concluded with free stone status and 12% developed major complications. 66% fulfilled the proposed success definition. In the first conjunct consolidation, a positive urine culture and a complex stone were identified as risk factors; after making one more conjunction with another stratum, the severe Charlson Comorbidity Index (CCI) was also identified as a risk factor. Finally, an operating time ≥ 120 minutes was added as an intraoperative factor that increases risk.
The variables positive urine culture, severe CCI, complex stone and prolonged operating time are associated with major complications and residual stone. The proposed score is a simple and predictive tool that can be used in daily practice, given that it includes 3 pre-operative variables. The treatment success or failure rate of the score can be applied in the selection of patients ongoing PNL.
经皮肾镜取石术(PNL)是直径>2 cm肾结石的一线治疗方法。目前用于衡量该手术成功与否的评分仅考虑结石清除情况,未考虑并发症。
提出一种新的预后分层系统,以预测PNL治疗失败情况。
回顾性队列研究,确定预后因素及有无并发症的残余结石作为治疗失败情况。对数值变量进行双变量分析,并通过联合合并建立预后分层系统。
共纳入595例病例,其中73%结石清除,12%发生严重并发症。66%符合拟定的成功定义。在首次联合合并中,尿培养阳性和复杂性结石被确定为危险因素;在与另一分层再进行一次合并后,严重查尔森合并症指数(CCI)也被确定为危险因素。最后,增加手术时间≥120分钟作为增加风险的术中因素。
尿培养阳性、严重CCI、复杂性结石和手术时间延长等变量与严重并发症和残余结石相关。拟定的评分是一种简单且具有预测性的工具,可用于日常实践,因其包含3个术前变量。该评分的治疗成功率或失败率可应用于正在接受PNL治疗的患者选择。