Wan Mengjie, Yang Xiaoyang
Department of Dermatology, Affiliated Haikou Hospital, Xiangya School Central South University and Haikou Municipal Municipal People's Hospital, Haikou, China.
Department of Hematology, Affiliated Haikou Hospital, Xiangya School Central South University and Haikou Municipal Municipal People's, Haikou, China.
Int Arch Allergy Immunol. 2024 Nov 27:1-12. doi: 10.1159/000542777.
This review aimed to examine if atopic dermatitis (AD) led to an increased risk of inflammatory bowel disease (IBD) by collating data from longitudinal studies.
Cohort and case-control studies examining the risk of IBD, Crohn's disease (CD), or ulcerative colitis (UC) due to exposure to AD were included in this review. Articles were searched on PubMed, CENTRAL, Embase, Scopus, and Web of Science electronic repositories up to 2nd October 2024.
Eight retrospective cohort studies with 61,190,816 participants were included. The meta-analysis found that AD was a significant risk factor for IBD (OR: 1.37; 95% CI: 1.31, 1.43). No statistical heterogeneity was noted. Pooled analysis showed that exposure to AD was a significant risk factor for both CD (OR: 1.51; 95% CI: 1.31, 1.76) and UC (OR: 1.33; 95% CI: 1.13, 1.56). Both meta-analyses had high inter-study heterogeneity with I2 = 83% and I2 = 89%, respectively. Results remained significant on sensitivity analysis.
Our study shows an association between AD and IBD. The association was persistent for both CD and UC. Given the small increase in risk of IBD in AD, its clinical relevance may be questionable.
本综述旨在通过整理纵向研究的数据，探讨特应性皮炎（AD）是否会增加炎症性肠病（IBD）的风险。
本综述纳入了队列研究和病例对照研究，这些研究考察了因接触AD而导致IBD、克罗恩病（CD）或溃疡性结肠炎（UC）的风险。截至2024年10月2日，在PubMed、CENTRAL、Embase、Scopus和Web of Science电子数据库中检索相关文章。
纳入了八项回顾性队列研究，共61190816名参与者。荟萃分析发现，AD是IBD的一个显著风险因素（OR：1.37；95%CI：1.31，1.43）。未发现统计学异质性。汇总分析表明，接触AD是CD（OR：1.51；95%CI：1.31，1.76）和UC（OR：1.33；95%CI：1.13，1.56）的显著风险因素。两项荟萃分析的研究间异质性都很高，I2分别为83%和89%。敏感性分析结果仍然显著。
我们的研究表明AD与IBD之间存在关联。这种关联在CD和UC中均持续存在。鉴于AD中IBD的风险增加幅度较小，其临床相关性可能存疑。
