迷幻剂在阿尔茨海默病相关痴呆中的免疫调节作用。
The immunomodulatory effects of psychedelics in Alzheimer's disease-related dementia.
作者信息
Mohammad Hosseini Alireza, Khaleghzadeh-Ahangar Hossein, Rahimi Atena
机构信息
Babol University of Medical Sciences, Babol, Iran.
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran; Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
出版信息
Neuroscience. 2025 Jan 9;564:271-280. doi: 10.1016/j.neuroscience.2024.11.062. Epub 2024 Nov 26.
Dementia is an increasing disorder, and Alzheimer's disease (AD) is the cause of 60% of all dementia cases. Despite all efforts, there is no cure for stopping dementia progression. Recent studies reported potential effects of psychedelics on neuroinflammation during AD. Psychedelics by 5HTR activation can reduce proinflammatory cytokine levels (TNF-α, IL-6) and inhibit neuroinflammation. In addition to neuroinflammation suppression, psychedelics induce neuroplasticity by increasing Brain-derived neurotrophic factor (BDNF) levels through Sigma-1R stimulation. This review discussed the effects of psychedelics on AD from both neuroinflammatory and neuroplasticity standpoints.
痴呆症是一种日益常见的疾病，而阿尔茨海默病（AD）是所有痴呆症病例的60%的病因。尽管人们做出了种种努力，但仍无法治愈以阻止痴呆症的进展。最近的研究报告了迷幻剂对AD期间神经炎症的潜在影响。通过5HTR激活的迷幻剂可以降低促炎细胞因子水平（TNF-α、IL-6）并抑制神经炎症。除了抑制神经炎症外，迷幻剂还通过Sigma-1R刺激增加脑源性神经营养因子（BDNF）水平来诱导神经可塑性。本综述从神经炎症和神经可塑性两个角度讨论了迷幻剂对AD的影响。
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