Wang Yiyang, Wu Weijia, Zeng Fanqi, Meng Xiangyuan, Peng Mei, Wang Juan, Chen Zeyu, Liu Wenfeng
Hunan Provincial Key Laboratory of Physical Fitness and Sports Rehabilitation, Hunan Normal University, Changsha 410012, China.
Hunan Provincial Key Laboratory of Physical Fitness and Sports Rehabilitation, Hunan Normal University, Changsha 410012, China; Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, Hunan Normal University, Changsha 410081, China.
Exp Neurol. 2025 Feb;384:115070. doi: 10.1016/j.expneurol.2024.115070. Epub 2024 Nov 26.
In recent years, the role of the microbiome-gut-brain axis in the pathogenesis of Alzheimer's disease (AD) has garnered increasing attention. Specifically, tryptophan metabolism via the kynurenine pathway (KP) plays a crucial regulatory role in this axis. This study reviews how exercise regulates the microbiome-gut-brain axis by influencing kynurenine pathway metabolism, thereby exerting resistance against AD. This paper also discusses how exercise positively impacts AD via the microbiome-gut-brain axis by modulating the endocrine, autonomic nervous, and immune systems. Although the specific mechanisms are not fully understood, research indicates that exercise may optimize tryptophan metabolism by promoting the growth of beneficial microbiota and inhibiting harmful microbiota, producing substances that are beneficial to the nervous system and combating AD. The aim of this review is to provide new perspectives and potential intervention strategies for the prevention and treatment of AD by exploring the links between exercise, KP and the gut-brain axis.
近年来，微生物群-肠-脑轴在阿尔茨海默病（AD）发病机制中的作用日益受到关注。具体而言，色氨酸通过犬尿氨酸途径（KP）的代谢在该轴中发挥着关键的调节作用。本研究综述了运动如何通过影响犬尿氨酸途径代谢来调节微生物群-肠-脑轴，从而对AD产生抵抗作用。本文还讨论了运动如何通过调节内分泌、自主神经和免疫系统，经由微生物群-肠-脑轴对AD产生积极影响。尽管具体机制尚未完全明确，但研究表明，运动可能通过促进有益微生物群的生长和抑制有害微生物群，产生对神经系统有益的物质并对抗AD，从而优化色氨酸代谢。本综述的目的是通过探索运动、KP和肠-脑轴之间的联系，为AD的预防和治疗提供新的视角和潜在的干预策略。
