Aix-Marseille University, APHM, Department of Respiratory Medicine and Lung Transplantation, Marseille, France.
Aix-Marseille University, INSERM, INRAE, C2VN, Marseille, France.
Eur Respir Rev. 2024 Nov 27;33(174). doi: 10.1183/16000617.0093-2024. Print 2024 Oct.
Lung transplantation, a critical intervention for end-stage lung diseases, is frequently challenged by post-transplant complications. Indeed, primary graft dysfunction, anastomotic complications, infections and acute and chronic rejections pose significant hurdles in lung transplantation. While evidence regarding the role of airway epithelium after lung transplantation is still emerging, its importance is becoming increasingly recognised. This review looks at the complex involvement of airway epithelium in various post-transplant complications, while emphasising the utility of airway epithelial culture as a research model. In summary, by elucidating the involvement of airway epithelium in each post-transplant complication and explaining these intricate processes, the review aims to guide specific future research efforts and therapeutic strategies aimed at improving lung transplant outcomes and enhancing patient care.
肺移植是治疗终末期肺部疾病的关键手段，但经常受到移植后并发症的挑战。实际上，原发性移植物功能障碍、吻合口并发症、感染以及急性和慢性排斥反应给肺移植带来了重大障碍。尽管关于肺移植后气道上皮作用的证据仍在不断涌现，但它的重要性正日益受到重视。本综述探讨了气道上皮在各种移植后并发症中的复杂作用，同时强调了气道上皮培养作为一种研究模型的实用性。总之，通过阐明气道上皮在每种移植后并发症中的作用，并解释这些复杂的过程，本综述旨在为提高肺移植效果和改善患者护理的具体未来研究工作和治疗策略提供指导。
