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杜氏花萼提取物通过MAPK和NF-κB信号通路的抗炎作用

Anti-Inflammatory Effect of Extract from Duch. Calyx via MAPK and NF-κB Signaling Pathway.

作者信息

Kim Hyo-Min, Yoo Dan-Hee, Kang Jung-Wook, Lee In-Chul, Bae Jong-Sup

机构信息

College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.

College of Fusion and Convergence, Seowon University, Cheongju 28674, Republic of Korea.

出版信息

J Microbiol Biotechnol. 2024 Dec 28;34(12):2662-2674. doi: 10.4014/jmb.2409.09044. Epub 2024 Oct 31.

DOI:10.4014/jmb.2409.09044
PMID:39604003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11733547/
Abstract

Currently, Fragaria ananassa Duch. are discarded as by-products except for the fruit part, so we developed a natural material using the top (= calyx), one of the by-products, and prepared an extract using 70% ethanol to investigate its effects on anti-inflammatory mechanisms. The polyphenol content of 70% ethanol extracts from Fragaria ananassa Duch. calyx was measured to be 265.86 ± 0.85 mg TAE/100 g, respectively. The antioxidant activity was confirmed through the electron donating ability and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical scavenging ability measurements. When extracts from Fragaria ananassa Duch. calyx was treated to LPS-induced RAW 264.7 cells, it was confirmed that the production of inflammation-related factors, NO, PGE, iNOS, COX-2, TNF-a, and IL-6, was inhibited. In addition, it was confirmed that extracts from Fragaria ananassa Duch. calyx affected the MAPK signaling pathway by reducing the protein expression of p-ERK, p-JNK, and p-p38, which are the upper signaling pathways. In addition, it was confirmed to reduce the protein expression of p-p65 and p-IκB, which are NF-κB signaling pathways. Therefore, this study suggests that extracts from Fragaria ananassa Duch. calyx affect the regulation of the production of major inflammation-related factors by inhibiting the MAPK and NF-κB signaling pathway. These results confirmed that extracts from Fragaria ananassa Duch. calyx have the potential to be developed as a new natural material with anti-inflammatory activity.

摘要

目前，除果实部分外，凤梨草莓（Fragaria ananassa Duch.）的其他部分都被当作副产品丢弃，因此我们利用其中一种副产品——顶部（即花萼）开发了一种天然材料，并使用70%乙醇制备了提取物，以研究其抗炎机制的作用。测定凤梨草莓（Fragaria ananassa Duch.）花萼70%乙醇提取物的多酚含量分别为265.86±0.85毫克TAE/100克。通过供电子能力和2,2'-联氮-双-（3-乙基苯并噻唑啉-6-磺酸）（ABTS）自由基清除能力测定来确认抗氧化活性。当将凤梨草莓（Fragaria ananassa Duch.）花萼提取物作用于脂多糖诱导的RAW 264.7细胞时，证实炎症相关因子NO、PGE、iNOS、COX-2、TNF-α和IL-6的产生受到抑制。此外，证实凤梨草莓（Fragaria ananassa Duch.）花萼提取物通过降低上游信号通路p-ERK、p-JNK和p-p38的蛋白表达，影响丝裂原活化蛋白激酶（MAPK）信号通路。另外，证实其可降低核因子κB（NF-κB）信号通路中p-p65和p-IκB的蛋白表达。因此，本研究表明凤梨草莓（Fragaria ananassa Duch.）花萼提取物通过抑制MAPK和NF-κB信号通路，影响主要炎症相关因子产生的调节。这些结果证实，凤梨草莓（Fragaria ananassa Duch.）花萼提取物有潜力被开发成为一种具有抗炎活性的新型天然材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/0a575472a880/jmb-34-12-2662-f11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/e76457a8e64b/jmb-34-12-2662-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/0a575472a880/jmb-34-12-2662-f11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/53649f781739/jmb-34-12-2662-f2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/fd21b1b364e3/jmb-34-12-2662-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/31b835777c95/jmb-34-12-2662-f5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/235e022829dc/jmb-34-12-2662-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/5081a83a850e/jmb-34-12-2662-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/8cd45a5ea06d/jmb-34-12-2662-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/064f/11733547/e76457a8e64b/jmb-34-12-2662-f10.jpg
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本文引用的文献

[1]
Inhibitory Effects of Decursin Derivative against Lipopolysaccharide-Induced Inflammation.

Pharmaceuticals (Basel). 2024-10-7

[2]
Pharmacological effects and the related mechanism of scutellarin on inflammation-related diseases: a review.

Front Pharmacol. 2024-8-12

[3]
Anti-inflammatory effects of Olive (olea europaea L.) fruit extract in LPS-stimulated RAW264.7 cells via MAPK and NF-κB signal pathways.

Mol Biol Rep. 2024-6-21

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A Pair of Epimers of Lignan Alleviate Neuroinflammatory Effects by Modulating iNOS/COX-2 and MAPK/NF-κB Signaling Pathways.

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