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从森林野生人参中提取的人参皂苷的表征及其体外抗氧化和抗炎活性

Characterization and In Vitro Antioxidant and Anti-Inflammatory Activities of Ginsenosides Extracted from Forest-Grown Wild L.

作者信息

Yang Yang, Xu Shan, Yang Kemeng, Sun Yuning, Yang Ruirui, Hu Yanan, Chen Guijie, Cai Huimei

机构信息

School of Tea and Food Science & Technology, Anhui Agricultural University, Hefei 230036, China.

State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, China.

出版信息

Foods. 2023 Nov 29;12(23):4316. doi: 10.3390/foods12234316.

DOI:10.3390/foods12234316
PMID:38231785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10706846/
Abstract

American ginseng ( L.) is known for its health benefits, which are attributed to various terpenoids. However, the specific composition and activities of these terpenoids in forest-grown wild American ginseng remain understudied. This study aimed to characterize the terpenoid composition, particularly triterpene saponins, in forest-grown wild American ginseng. The analysis revealed that triterpene saponins, notably American ginseng ginsenosides (AGGs), are the predominant active components, as identified through LC-MS/MS and HPLC. A subsequent in vitro evaluation of AGGs showcased their potent antioxidant capabilities, displaying the dose-dependent scavenging of free radicals and reducing agents. Moreover, AGGs demonstrated efficacy in reducing oxidative injury and intracellular ROS levels in RAW 264.7 macrophages treated with HO. In addition to their antioxidant properties, AGGs exhibited anti-inflammatory effects, significantly inhibiting NO and inflammatory substance production in lipopolysaccharide-treated RAW 264.7 macrophages. These findings highlight the potential of AGG-rich forest-grown wild American ginseng as a functional food with promising implications for improving human health.

摘要

西洋参（L.）因其对健康有益而闻名，这些益处归因于各种萜类化合物。然而，森林中生长的野生西洋参中这些萜类化合物的具体组成和活性仍未得到充分研究。本研究旨在表征森林中生长的野生西洋参中的萜类化合物组成，特别是三萜皂苷。分析表明，通过液相色谱-串联质谱法（LC-MS/MS）和高效液相色谱法（HPLC）鉴定，三萜皂苷，尤其是西洋参皂苷（AGGs）是主要的活性成分。随后对AGGs进行的体外评估显示出它们强大的抗氧化能力，表现出对自由基和还原剂的剂量依赖性清除作用。此外，AGGs在减少用HO处理的RAW 264.7巨噬细胞中的氧化损伤和细胞内活性氧水平方面显示出功效。除了其抗氧化特性外，AGGs还表现出抗炎作用，显著抑制脂多糖处理的RAW 264.7巨噬细胞中一氧化氮和炎性物质的产生。这些发现突出了富含AGG的森林中生长的野生西洋参作为一种功能性食品的潜力，对改善人类健康具有广阔的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/2ceb3aa48531/foods-12-04316-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/0079960f8873/foods-12-04316-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/27027c6febb1/foods-12-04316-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/cc5f8bd68b08/foods-12-04316-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/487d2824621d/foods-12-04316-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/2ceb3aa48531/foods-12-04316-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/0079960f8873/foods-12-04316-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/27027c6febb1/foods-12-04316-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/cc5f8bd68b08/foods-12-04316-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/487d2824621d/foods-12-04316-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d084/10706846/2ceb3aa48531/foods-12-04316-g005.jpg

相似文献

[1]
Characterization and In Vitro Antioxidant and Anti-Inflammatory Activities of Ginsenosides Extracted from Forest-Grown Wild L.

Foods. 2023-11-29

[2]
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[3]
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[5]
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[9]
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[10]
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引用本文的文献

[1]
Diverse rare ginsenosides derived from ginsenoside Re in aqueous methanol solution heterogeneous catalysis and identified by HPLC-MS.

RSC Adv. 2025-5-16

[2]
Therapeutic effects of Huangqi formula (Eefooton) in chronic kidney disease: clinical research and narrative literature review.

Aging (Albany NY). 2024-12-7

[3]
Anti-Inflammatory Effect of Extract from Duch. Calyx via MAPK and NF-κB Signaling Pathway.

J Microbiol Biotechnol. 2024-12-28

本文引用的文献

[1]
Safety evaluation of rare ginsenosides of stems and leaves from American ginseng: 90-day exposure toxicity study combined with intestinal flora analysis and metabonomics in rats.

Ecotoxicol Environ Saf. 2023-10-1

[2]
Application of UPLC-Triple TOF-MS/MS metabolomics strategy to reveal the dynamic changes of triterpenoid saponins during the decocting process of Asian ginseng and American ginseng.

Food Chem. 2023-10-30

[3]
Pharmacokinetics and Oral Bioavailability of Saponins Administered to Rats Using a Validated UPLC-MS/MS Method.

J Agric Food Chem. 2023-1-11

[4]
In vitro antioxidant analysis of flavonoids extracted from Artemisia argyi stem and their anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.

Food Chem. 2023-5-1

[5]
Ginsenosides are active ingredients in with immunomodulatory properties from cellular to organismal levels.

J Ginseng Res. 2022-11

[6]
Pharmacological properties, molecular mechanisms and therapeutic potential of ginsenoside Rg3 as an antioxidant and anti-inflammatory agent.

Front Pharmacol. 2022-9-5

[7]
Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects.

J Ginseng Res. 2022-3

[8]
Terpenoids and Polyphenols as Natural Antioxidant Agents in Food Preservation.

Antioxidants (Basel). 2021-8-8

[9]
Senescence-associated hyper-activation to inflammatory stimuli .

Aging (Albany NY). 2021-8-10

[10]
Pharmacological potential of ginseng and its major component ginsenosides.

J Ginseng Res. 2021-3

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