Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Internal Medicine, School of Medicine, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Sci Rep. 2024 Nov 27;14(1):29481. doi: 10.1038/s41598-024-80787-3.
Trace elements, specifically magnesium (Mg), zinc (Zn), and selenium (Se) have been linked with immunomodulatory properties. This research delves into identifying the potential impression of serum levels Mg, Zn, and Se on the protective immunity arisen through Sinopharm COVID-19 vaccine in the vaccinated subjects. Levels of Mg, Zn, and Se, cytokine and antibody production as well as virus neutralization potency were investigated in 75 males and 75 females before and 2 weeks after first and second dose of vaccination. Level of Mg, Zn, and Se did not change significantly before and 2 weeks after first and second dose of vaccine administration. Concentrations of Interleukin (IL)-2, IL-6, and Interferon (IFN)-γ were significantly higher in the supernatant of peripheral blood mononuclear cells (PBMCs) obtained from subjects 2 weeks after both first and second dose of vaccination compared to before vaccination. Serum level IgG was significantly higher 2 weeks after first and second dose of vaccination compared to before vaccination. Serum level IgM was only higher after first dose of vaccination compared with before vaccine. Also, 2 weeks after both first and second dose of vaccination compared to before vaccination, FRNT titer was significantly higher. Levels of Mg, Zn, and Se did not significantly correlate with levels of IL-2, IL-6, IFN-γ, IgM and IgG, and FRNT after first and second dose of vaccination. No severe unwanted clinical symptoms were detected after vaccination. Mg, Zn, and Se do not play a role in modulating protective immunity during Sinopharm COVID-19 vaccine.
微量元素，特别是镁（Mg）、锌（Zn）和硒（Se），与免疫调节特性有关。本研究深入探讨了血清中 Mg、Zn 和 Se 水平对已接种人群接种国药控股 COVID-19 疫苗后产生的保护性免疫的潜在影响。在接种第一剂和第二剂疫苗前后，分别检测了 75 名男性和 75 名女性血清中 Mg、Zn 和 Se 水平、细胞因子和抗体产生以及病毒中和能力。接种第一剂和第二剂疫苗前后，Mg、Zn 和 Se 水平无明显变化。与接种前相比，接种第一剂和第二剂疫苗后 2 周，外周血单个核细胞（PBMCs）上清液中白细胞介素（IL）-2、IL-6 和干扰素（IFN）-γ的浓度显著升高。与接种前相比，接种第一剂和第二剂疫苗后 2 周，血清 IgG 水平显著升高。与接种前相比，仅在接种第一剂疫苗后，血清 IgM 水平升高。此外，与接种前相比，接种第一剂和第二剂疫苗后 2 周，FRNT 滴度显著升高。接种第一剂和第二剂疫苗后，Mg、Zn 和 Se 水平与 IL-2、IL-6、IFN-γ、IgM 和 IgG 以及 FRNT 水平均无显著相关性。接种后未发现严重不良反应。Mg、Zn 和 Se 在调节国药控股 COVID-19 疫苗的保护性免疫中不起作用。
