Liu Sijia, Ren Jiang, Hu Yanmei, Zhou Fangfang, Zhang Long
International Biomed-X Research Center, Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
The First Affiliated Hospital, MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Cell Regen. 2024 Nov 28;13(1):26. doi: 10.1186/s13619-024-00207-9.
Human stem cells are undifferentiated cells with the capacity for self-renewal and differentiation into distinct cell lineages, playing important role in the development and maintenance of diverse tissues and organs. The microenvironment of stem cell provides crucial factors and components that exert significant influence over the determination of cell fate. Among these factors, cytokines from the transforming growth factor β (TGFβ) superfamily, including TGFβ, bone morphogenic protein (BMP), Activin and Nodal, have been identified as important regulators governing stem cell maintenance and differentiation. In this review, we present a comprehensive overview of the pivotal roles played by TGFβ superfamily signaling in governing human embryonic stem cells, somatic stem cells, induced pluripotent stem cells, and cancer stem cells. Furthermore, we summarize the latest research and advancements of TGFβ family in various cancer stem cells and stem cell-based therapy, discussing their potential clinical applications in cancer therapy and regeneration medicine.
人类干细胞是具有自我更新能力并能分化为不同细胞谱系的未分化细胞，在多种组织和器官的发育与维持中发挥着重要作用。干细胞的微环境提供了对细胞命运决定产生重大影响的关键因子和成分。在这些因子中，来自转化生长因子β（TGFβ）超家族的细胞因子，包括TGFβ、骨形态发生蛋白（BMP）、激活素和Nodal，已被确定为调控干细胞维持和分化的重要调节因子。在本综述中，我们全面概述了TGFβ超家族信号在调控人类胚胎干细胞、体干细胞、诱导多能干细胞和癌症干细胞方面所起的关键作用。此外，我们总结了TGFβ家族在各种癌症干细胞和基于干细胞的治疗方面的最新研究和进展，讨论了它们在癌症治疗和再生医学中的潜在临床应用。
