School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, People's Republic of China.
School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.
J Headache Pain. 2024 Nov 27;25(1):208. doi: 10.1186/s10194-024-01911-2.
Previous research has shown an association between migraine and cardiovascular diseases (CVDs). However, limited studies have explored the progression of cardiovascular health (CVH) among individuals with migraine. This cohort study aimed to explore the relationship between changes in CVH and migraine among women of Chinese descent in Hong Kong.
Data from a cohort study titled "Migraine Exposures and Cardiovascular Health in Hong Kong Chinese Women (MECH-HK)" were analysed. A total of 2,603 women, averaging 56.5 ± 8.5 years of age, were selected, all with complete data at baseline and at a follow-up occurring on average 1.27 years later. CVH profile was assessed by an adapted Life's Essential 8, comprising dietary habits, physical activity, nicotine exposure, sleep duration, body mass index (BMI), lipid levels, blood pressure, and stress. Each component was scored from 0 to 100, with overall CVH as the average. CVH levels were categorized as low (0-49), moderate (50-79), and high (80-100), representing poor to excellent health. Changes in CVH were defined as shifts between these categories from baseline to subsequent follow-up. Migraine cases were identified utilizing the International Classification of Headache Disorders 3.
A total of 275 (10.6%) women were identified as having migraine. By follow-up, both women with and without migraine experienced significant declines in CVH profiles (all p-value < 0.05). In the fully adjusted model, women with migraine had a 1.36 times higher risk (OR 95% CI: 1.33, 1.39) of decline in overall CVH compared to non-migraineurs. They also had a higher likelihood of shifting to worse CVH levels in several individual CVH components, including physical activity (OR: 1.09), nicotine exposure (OR: 4.27), sleep quality (OR: 1.80), blood lipid levels (OR: 1.03), and stress (OR: 1.23) (all p-value < 0.05). Among women with migraine, those experiencing aura had a higher risk of poorer physical activity, greater nicotine exposure, higher BMI, and increased stress than those without aura (all p-value < 0.05).
Women with migraine exhibited worse progression in CVH compared to those without migraine. Targeted monitoring and management of CVH-related factors in this population are crucial to reducing their elevated risk of CVDs.
先前的研究表明偏头痛与心血管疾病（CVDs）之间存在关联。然而，有限的研究探讨了偏头痛患者心血管健康（CVH）的进展情况。本队列研究旨在探索香港华裔女性偏头痛患者中 CVH 变化与偏头痛之间的关系。
对一项名为“香港华裔女性偏头痛暴露与心血管健康（MECH-HK）”的队列研究的数据进行了分析。共选择了 2603 名女性，平均年龄为 56.5±8.5 岁，所有女性均在基线时和平均 1.27 年后的随访时具有完整数据。通过适应性的生活的 8 个要素来评估 CVH 特征，包括饮食习惯、身体活动、尼古丁暴露、睡眠持续时间、体重指数（BMI）、血脂水平、血压和压力。每个组成部分的评分范围为 0 到 100，总体 CVH 为平均值。CVH 水平分为低（0-49）、中（50-79）和高（80-100），代表健康状况从差到优。从基线到后续随访时，CVH 的变化定义为这些类别之间的转移。利用国际头痛疾病分类 3 确定偏头痛病例。
共有 275 名（10.6%）女性被确定为偏头痛患者。随访时，有偏头痛和无偏头痛的女性 CVH 特征均显著下降（所有 p 值均<0.05）。在完全调整的模型中，与非偏头痛患者相比，偏头痛患者整体 CVH 下降的风险高 1.36 倍（OR 95%CI：1.33，1.39）。她们在几个单独的 CVH 组成部分中向更差的 CVH 水平转变的可能性也更高，包括身体活动（OR：1.09）、尼古丁暴露（OR：4.27）、睡眠质量（OR：1.80）、血脂水平（OR：1.03）和压力（OR：1.23）（所有 p 值均<0.05）。在偏头痛女性中，有先兆偏头痛的女性在身体活动、尼古丁暴露、BMI 和压力方面的风险高于无先兆偏头痛的女性（所有 p 值均<0.05）。
与无偏头痛的女性相比，偏头痛女性的 CVH 恶化程度更差。在该人群中，针对 CVH 相关因素进行有针对性的监测和管理对于降低其 CVD 风险至关重要。
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