School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
BMJ Open. 2024 Jul 16;14(7):e084228. doi: 10.1136/bmjopen-2024-084228.
Evidence about the associations of migraine features with cardiovascular risk profiles in Chinese population is lacking. The Migraine Exposures and Cardiovascular Health in Hong Kong Chinese Women (MECH-HK) cohort was constructed to investigate longitudinal migraine features and their cardiovascular implications in Hong Kong Chinese women.
We enrolled 4221 Hong Kong Chinese women aged 30 years or above from October 2019 to December 2020. Demographics, reproductive information, lifestyle factors, disease history, blood lipids and glucose, anthropometrics and body compositions were measured during baseline and follow-up. Migraine diagnosis followed the International Classification of Headache Disorders-3 criteria. Migraine features were longitudinally tracked using a migraine diary and summarised by a wide range of epidemiological metrics. Cardiovascular health was assessed using the Framingham risk score (FRS).
From October 2021 to June 2023, 3455 women completed the first follow-up measurement. The retention rate was 81.9%. The average age at baseline was 54.40 years. The mean blood glucose, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were 6.44 mmol/L, 65.06 mg/dL and 102.40 mg/dL, respectively. The average FRS was 0.06. Participants had a 10.3% prevalence of migraine or probable migraine. After 1.27 years of follow-up, the median migraine attack frequency was 0.99 attacks/month, with an incidence rate of 2.55 attacks/person-month and a median duration of 7.70 hours/attack. Sleep problems (64.7%) and stress (54.0%) were the top triggers, while prevalent accompanying symptoms were nausea (67.4%), photophobia (39.9%), phonophobia (30.0%) and vomiting (26.2%). Migraine auras included blurred visions (59.6%), flashing lights (41.3%), blind spots (33.0%), pins and needles (6.4%) and halo (1.8%).
The follow-up for the cohort will be implemented every 2 years. MECH-HK will provide unique longitudinal data on migraine features in Hong Kong women. The linkage between migraine features and cardiovascular disease risk progression will be identified by a long-term observation.
关于偏头痛特征与中国人群心血管风险特征之间关联的证据尚缺乏。本研究构建了香港华裔女性偏头痛暴露与心血管健康（MECH-HK）队列，旨在调查香港华裔女性偏头痛特征及其心血管意义的纵向变化。
我们纳入了 2019 年 10 月至 2020 年 12 月期间年龄在 30 岁及以上的 4221 名香港华裔女性。在基线和随访期间，测量了人口统计学资料、生殖信息、生活方式因素、疾病史、血脂和血糖、人体测量学和身体成分。偏头痛诊断采用国际头痛疾病分类第 3 版标准。使用偏头痛日记对偏头痛特征进行纵向跟踪，并采用多种流行病学指标进行总结。采用弗雷明汉风险评分（FRS）评估心血管健康状况。
自 2021 年 10 月至 2023 年 6 月，3455 名女性完成了第一次随访测量。保留率为 81.9%。基线时的平均年龄为 54.40 岁。平均血糖、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平分别为 6.44mmol/L、65.06mg/dL 和 102.40mg/dL。平均 FRS 为 0.06。参与者偏头痛或可能偏头痛的患病率为 10.3%。随访 1.27 年后，中位数偏头痛发作频率为每月 0.99 次，发病率为 2.55 次/人月，中位数每次发作持续时间为 7.70 小时。睡眠问题（64.7%）和压力（54.0%）是最常见的诱因，而常见的伴随症状是恶心（67.4%）、畏光（39.9%）、恐声（30.0%）和呕吐（26.2%）。偏头痛先兆包括模糊视野（59.6%）、闪光（41.3%）、盲点（33.0%）、刺痛感（6.4%）和光环（1.8%）。
该队列的随访将每 2 年进行一次。MECH-HK 将提供香港女性偏头痛特征的独特纵向数据。通过长期观察，确定偏头痛特征与心血管疾病风险进展之间的关系。
