Stolpegaard Psychotherapy Centre, Mental Health Services, Capital Region of Denmark, Stolpegaardsvej 20, Gentofte, 2820, Denmark.
Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.
Syst Rev. 2024 Nov 27;13(1):292. doi: 10.1186/s13643-024-02697-9.
Offspring of parents with a mental disorder are at high risk of a range of adverse outcomes, highlighting the need for preventive interventions. However, a comprehensive overview of the beneficial and harmful effects of preventive interventions for parents with mental disorders on offspring outcomes are uncertain. The main objective of this systematic review will be to assess the effects of preventive interventions versus any control intervention for parents with a mental disorder on offspring outcomes.
METHODS/DESIGN: We will conduct a systematic review with meta-analysis and report it as recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), bias will be assessed with the Cochrane Risk of Bias tool-version 2 (ROB2), an eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, trial sequential analysis will be conducted to control for random errors, and the certainty of the evidence will be assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. To identify relevant trials, we will search for published trials in several electronic databases from their inception to the present. We will also search for unpublished trials and grey literature. Two review authors will independently screen the articles, extract data, and perform a risk of bias assessment. We will include any published or unpublished randomized clinical trial comparing a psychological preventive intervention versus any control intervention for parents with any mental disorder. The primary outcomes will be quality of life and incidence of a mental disorder. Secondary outcomes will include internalizing symptoms, externalizing symptoms, serious adverse events, out-of-home placement, and absence from school or daycare. Exploratory outcomes include trauma, socioemotional development, and language development. All outcomes will be assessed in offsping only.
There is an urgent need for a comprehensive, updated systematic review of the beneficial and harmful effects of preventive interventions for children of parents with a mental disorder. The findings of this systematic review are expected to provide evidence-based information for policymakers, clinicians, and researchers to help them make informed decisions about the most effective interventions and guide future research for this highly prevalent population.
PROSPERO CRD42023463421.
父母患有精神障碍的子女存在一系列不良后果的高风险，这突显了预防干预的必要性。然而，对于精神障碍父母的预防干预对子女结局的有益和有害影响，目前还没有全面的概述。本系统评价的主要目的将是评估预防干预与任何对照干预对精神障碍父母的子女结局的影响。
方法/设计：我们将进行系统评价和荟萃分析，并按照系统评价和荟萃分析的首选报告项目（PRISMA）的建议进行报告，偏倚将使用 Cochrane 风险偏倚工具-2（ROB2）进行评估，将使用八步程序评估是否跨越了临床意义的阈值，将进行试验序贯分析以控制随机误差，并使用推荐评估、制定和评估（GRADE）方法评估证据的确定性。为了确定相关试验，我们将从成立之初到现在，在多个电子数据库中搜索已发表的试验。我们还将搜索未发表的试验和灰色文献。两名综述作者将独立筛选文章、提取数据和进行风险偏倚评估。我们将纳入任何比较父母任何精神障碍的心理预防干预与任何对照干预的已发表或未发表的随机临床试验。主要结局将是生活质量和精神障碍的发生率。次要结局将包括内化症状、外化症状、严重不良事件、离家安置以及缺课或日托。探索性结局包括创伤、社会情感发展和语言发展。所有结局都将仅在子女中进行评估。
对于父母患有精神障碍的子女的预防干预的有益和有害效果，有一个紧迫的需要进行全面、更新的系统评价。本系统评价的结果预计将为政策制定者、临床医生和研究人员提供基于证据的信息，帮助他们就最有效的干预措施做出明智的决策，并指导针对这一高度流行人群的未来研究。
PROSPERO CRD42023463421。
